SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols

  • Heinrich Berger
  • Werner Seebacher
  • Marcel Kaiser
  • Reto Brun
  • Robert Saf
  • Robert Weis
Original Paper
First Online:
Received:
Accepted:

Abstract

Several 4-amino-6,7-diarylbicyclo[2.2.2]octan-2-ols bearing varying substituents on the aromatic rings were synthesized following a manual method for applying the Hansch approach. All new compounds were tested for their activity against the causative organisms of East African sleeping sickness and malaria tropica. Structure activity relationships are discussed.

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Keywords

Amino alcohols Drug research East African sleeping sickness Malaria tropica Structure-activity relationships 
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Notes

Acknowledgments

This work was supported by the Austrian Science Fund (Fonds zur Förderung der wissenschaftlichen Forschung), grant no. P-15928, by several research grants of the Karl Franzens University of Graz and by the Bank Austria Creditanstalt.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Heinrich Berger
    • 1
  • Werner Seebacher
    • 1
  • Marcel Kaiser
    • 2
  • Reto Brun
    • 2
  • Robert Saf
    • 3
  • Robert Weis
    • 1
  1. 1.Institute of Pharmaceutical Sciences, Pharmaceutical ChemistryUniversity of GrazGrazAustria
  2. 2.Swiss Tropical InstituteBaselSwitzerland
  3. 3.Institute of Chemical Technology of Organic MaterialsErzherzog-Johann UniversityGrazAustria

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