Synthesis of anticancer compounds, III (Bioorg Med Chem Lett 17, 6091, 2007), carbinol derivatives of azanaphthoquinone annelated pyrroles

  • Nipawan Pongprom
  • Gerhard Müller
  • Peter Schmidt
  • Wolfgang Holzer
  • Helmut Spreitzer
Original Paper


A series of carbinols has been synthesized by attachment of different piperidinyl side chains to the quinone structure of azanaphthoquinone annelated pyrroles. The synthesized compounds were screened for their cytotoxic activities. Compared to previously published results, they exhibited only moderate activities, thus showing that the existence of the quinone moiety seems to be essential for anticancer activities of this group.

Graphical abstract


Azanaphthoquinone Anticancer agents Heterocycles Carbinols 



N. Pongprom thanks The Royal Thai Government Scholarship for financial support throughout her PhD program.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Department of Drug and Natural Product SynthesisUniversity of ViennaViennaAustria
  2. 2.Zentaris GmbHDrug Discovery and Preclinical DevelopmentFrankfurtGermany

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