The Synthesis of Novel Methotrexate-like Compounds
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- Çolak, N., Yıldırır, Y., Kavutcu, M. et al. Monatsh. Chem. (2007) 138: 1283. doi:10.1007/s00706-007-0716-0
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Methotrexate (MTX) is a folate antagonist used in treatment of several chronic inflammatory and neoplastic conditions. In this study, new MTX-like compounds that may-be potential anticancer agents were synthesized and their structures were determined by IR, UV, GC-MS, 1H NMR, and 13C NMR spectra. Also, in this study, a series structurally related to MTX or folate analogous compounds were evaluated whether they have inhibitory properties on the dihydrofolate reductase activity (DHFR).