Monatshefte für Chemie - Chemical Monthly

, Volume 138, Issue 12, pp 1283–1287

The Synthesis of Novel Methotrexate-like Compounds

  • Naki Çolak
  • Yılmaz Yıldırır
  • Mustafa Kavutcu
  • Nilhan Nurlu
Article

DOI: 10.1007/s00706-007-0716-0

Cite this article as:
Çolak, N., Yıldırır, Y., Kavutcu, M. et al. Monatsh. Chem. (2007) 138: 1283. doi:10.1007/s00706-007-0716-0

Summary.

Methotrexate (MTX) is a folate antagonist used in treatment of several chronic inflammatory and neoplastic conditions. In this study, new MTX-like compounds that may-be potential anticancer agents were synthesized and their structures were determined by IR, UV, GC-MS, 1H NMR, and 13C NMR spectra. Also, in this study, a series structurally related to MTX or folate analogous compounds were evaluated whether they have inhibitory properties on the dihydrofolate reductase activity (DHFR).

Keywords. Methotrexate; p-Aminobenzoic acid; DMAP; DCC; Amino acid esters. 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Naki Çolak
    • 1
  • Yılmaz Yıldırır
    • 1
  • Mustafa Kavutcu
    • 2
  • Nilhan Nurlu
    • 2
  1. 1.Department of Chemistry, Faculty of Science and ArtsGazi UniversityAnkaraTurkey
  2. 2.Department of Medical Biochemistry, Faculty of MedicineGazi UniversityAnkaraTurkey

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