Archives of Virology

, Volume 147, Issue 8, pp 1657–1661 | Cite as

The award of the “Interbrew-Baillet Latour de la Santé — 2002” prize to Robert M. Krug for outstanding contributions to influenza virus research

  • Bertha-Cecilia Ramirez
  • M. Bouloy
  • A.-L. Haenni


Influenza Influenza Virus Viral mRNAs NS1A Protein NS1B Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Beaton AR, Krug RM (1986) Transcription antitermination during influenza viral template RNA synthesis requires the nucleocapsid protein and the absence of a 5′ capped end. Proc Natl Acad Sci USA 83: 6282–6286PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Bouloy M, Plotch SJ, Krug RM (1978) Globin mRNAs are primers for the transcription of influenza viral RNA in vitro. Proc Natl Acad Sci USA 75: 4886–4890PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Braam J, Ulmanen I, Krug RM (1983) Molecular model of a eukaryotic transcription complex: functions and movements of influenza P proteins during capped RNA-primed transcription. Cell 34: 609–618PubMedCrossRefGoogle Scholar
  4. 4.
    Chen Z, Li Y, Krug RM (1999) Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3′ end processing machinery. EMBO J 18: 2273–2283PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Chien C, Tejero R, Huang Y, Zimmerman, Krug RM, Montelione GT (1997) A novel RNA-binding motif in influenza A virus non-structural protein 1. Nature Struct Biol 4: 891–895PubMedCrossRefGoogle Scholar
  6. 6.
    Herz C, Stavnezer E, Krug RM, Gurney T (1981) Influenza virus, an RNA virus, synthesizes its messenger RNA in the nucleus of infected cells. Cell 26: 391–400PubMedCrossRefGoogle Scholar
  7. 7.
    Li M-L, Ramirez BC, Krug RM (1998) RNA-dependent activation of primer RNA production by the influenza virus polymerase: different regions of the same protein subunit constitute the two required RNAbinding sites. EMBO J 17: 5844–5852PubMedCentralPubMedCrossRefGoogle Scholar
  8. 8.
    Li M-L, Rao P, Krug RM (2001) The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits. EMBO J 20: 2078–2086PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Li Y, Yamakita Y, Krug RM (1998) Regulation of a nuclear export signal by an adjacent inhibitory sequence: the effector domain of the influenza virus NS1 protein. Proc Natl Acad Sci USA 95: 4864–4869PubMedCentralPubMedCrossRefGoogle Scholar
  10. 10.
    Li Y, Chen Z-Y, Wang W, Baker CC, Krug RM (2001) The 3′ end processing factor CPSF is required for the splicing of single intron pre-mRNAs in vivo. RNA 7: 920–931PubMedCentralPubMedCrossRefGoogle Scholar
  11. 11.
    Liu J, Lynch PA, Chien C, Montelione GT, Krug RM, Berman HM (1997) Crystal structure of the unique multifunctional RNA-binding domain of the influenza virus NS1 protein. Nature Struct Biol 4: 896–899PubMedCrossRefGoogle Scholar
  12. 12.
    Lu Y, Wambach M, Katze MG, Krug RM (1995) Binding of the influenza virus NS1 protein to doublestranded RNA inhibits the activation of the protein kinase that phosphorylates the eIF-2 translation initiation factor. Virology 214: 222–228PubMedCrossRefGoogle Scholar
  13. 13.
    Nemeroff ME, Barabino SML, Li Y, Keller W, Krug RM (1998) Influenza virus NS1 protein interacts with the cellular 30kD subunit of CPSF and inhibits 3′ end formation of cellular mRNAs. Mol Cell 1: 991–1000PubMedCrossRefGoogle Scholar
  14. 14.
    Plotch SJ, Bouloy M, Krug RM (1979) Transfer of the 5′ terminal cap of globin mRNA to influenza viral complementary RNA during transcription in vitro. Proc Natl Acad Sci USA 76: 1618–1622PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Plotch SJ, Bouloy M, Ulmanen I, Krug RM (1981) A unique cap (m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription. Cell 23: 847–858PubMedCrossRefGoogle Scholar
  16. 16.
    Qian X-Y, Alonso-Caplen F, Qui Y, Krug RM (1994) Two functional domains of the influenza NS1 protein are required for the regulation of the nuclear export of mRNA. J Virol 68: 2433–2441PubMedCentralPubMedGoogle Scholar
  17. 17.
    Shapiro GI, Gurney T, Krug RM (1987) Influenza viral gene expression: control mechanisms at early and late times of infection and nuclear-cytoplasmic transport of virus-specific RNAs. J Virol 61: 763–773Google Scholar
  18. 18.
    Shih SR, Nemeroff M, Krug RM (1995) The choice of alternative 5′ splice sites in influenza virus M1 mRNA is regulated by the viral polymerase complex. Proc Natl Acad Sci USA 92: 6324–6328PubMedCentralPubMedCrossRefGoogle Scholar
  19. 19.
    Shih SR, Krug RM (1996) Novel exploitation of a nuclear function by influenza virus: the cellular SF2/ASF splicing factor controls the amount of the essential M2 ion channel protein in infected cells. EMBO J 15: 5415–5427PubMedCentralPubMedGoogle Scholar
  20. 20.
    Shih SR, Krug RM (1996) Surprising function of the three influenza viral polymerase proteins: selective protection of viral mRNAs against the cap-snatching reaction catalyzed by the same polymerase proteins. Virology 226: 430–435PubMedCrossRefGoogle Scholar
  21. 21.
    Wang W, Krug RM (1996) The binding and effector domains of the viral NS1 protein are conserved to different extents among influenza A and B viruses. Virology 223: 41–50PubMedCrossRefGoogle Scholar
  22. 22.
    Wang W, Riedel K, Lynch K, Chien C, Montelione GT, Krug RM (1999) RNA-binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids. RNA 5: 195–205PubMedCentralPubMedCrossRefGoogle Scholar
  23. 23.
    Yuan W, Krug RM (2001) Influenza B virus NS1 protein inhibits conjugation of the IFN-induced, ubiquitinlike ISG15 protein. EMBO J 20: 362–371PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 2002

Authors and Affiliations

  • Bertha-Cecilia Ramirez
    • 1
  • M. Bouloy
    • 2
  • A.-L. Haenni
    • 3
  1. 1.Institut des Sciences du Végétal, CNRS, F-91198 Gif-sur-YvetteFrance
  2. 2.Institut Pasteur, ParisFrance
  3. 3.Institut Jacques Monod, CNRS et Universités Paris, ParisFrance

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