Archives of Virology

, Volume 145, Issue 11, pp 2411–2420

Murine gammaherpesvirus M11 gene product inhibits apoptosis and is expressed during virus persistence

  • D. J. Roy
  • B. C. Ebrahimi
  • B. M. Dutia
  • A. A. Nash
  • J. P. Stewart
Brief Report

DOI: 10.1007/s007050070030

Cite this article as:
Roy, D., Ebrahimi, B., Dutia, B. et al. Arch. Virol. (2000) 145: 2411. doi:10.1007/s007050070030

Summary.

 The murine gammaherpesvirus (MHV-68) M11 gene encodes a protein with BH1 domain homology to Bcl-2. We found that the M11 gene product (MHVBcl-2) protected murine epithelial cells from TNF-α induced apoptosis. M11 was transcribed during early lytic infection in vitro. During early infection of mice, M11 message was detected in spleen and lung along with lytic cycle messages. During persistence, lytic cycle gene expression was undetectable but M11 RNA was still present. This suggests that MHVBcl-2 promotes virus survival by protecting not only productively infected but also persistently infected cells from apoptotic death.

Copyright information

© Springer-Verlag/Wien 2000

Authors and Affiliations

  • D. J. Roy
    • 1
  • B. C. Ebrahimi
    • 1
  • B. M. Dutia
    • 1
  • A. A. Nash
    • 1
  • J. P. Stewart
    • 1
  1. 1.Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K.GB

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