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Archives of Virology

, Volume 144, Issue 6, pp 1191–1200 | Cite as

IFNγ inhibits porcine reproductive and respiratory syndrome virus replication in macrophages

  • E. M. Bautista
  • T. W. Molitor
Brief Report

Summary

This study reports the effect of IFNγ on the replication of porcine reproductive and respiratory syndrome virus (PRRSV) in macrophages. Pretreatment with IFNγ profoundly affected PRRSV replication in porcine macrophages evaluated by reduction in titer and percentage of positive cells. The effect of IFNγ on PRRSV replication was both dose-dependent and related to the time of exposure. The mechanism of action was not due to blocking virus attachment. The inhibitory effect on PRRSV replication in macrophages suggests that IFNγ may play an important role in protection.

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Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • E. M. Bautista
    • 1
  • T. W. Molitor
    • 1
  1. 1.Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, U.S.A.USA

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