Archives of Virology

, Volume 145, Issue 3, pp 535–540 | Cite as

High frequency of postnatal transmission of TT virus in infancy

  • A. Kazi
  • H. Miyata
  • K. Kurokawa
  • M. A. Khan
  • T. Kamahora
  • S. Katamine
  • S. Hino

Abstract.

 DNA of TT virus (TTV), a novel human circovirus, was tested for in 116 mother-infant pairs who had participated in the adult T-cell leukemia prevention program (APP) in Nagasaki, Japan, and refrained from breast-feeding. By polymerase chain reaction with Okamoto’s seminested primers, 36 of the 115 (31%) mothers were positive. At the age of 6–8 months, 7 of 29 (24%) and 6 of 72 (8%) infants born to infected and uninfected mothers were positive, respectively (P = 0.047; RR, 2.90). Maternal TTV DNA load did not correlate with infantile infections. Since 99 of 100 (99%) cord blood samples were negative and all the mothers refrained from breast-feeding, the infantile TTV transmission would not be intrauterine or milk-borne. Between 6–8 and 12–21 months of age, 4 of 12 (33%) and 5 of 22 (23%) children born to infected and uninfected mothers turned positive, respectively (NS). At 12–21 months of age, 8 of 21 (38%) and 12 of 32 (38%) children born to infected and uninfected mothers were positive, respectively (NS). These results indicate that the TTV infection prevails in children at a frequency comparative to that in their mothers within the first 2 years of life, regardless of the maternal TTV status.

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Copyright information

© 2000 Springer-Verlag/ Wien

Authors and Affiliations

  • A. Kazi
    • 1
  • H. Miyata
    • 1
  • K. Kurokawa
    • 2
  • M. A. Khan
    • 1
  • T. Kamahora
    • 1
  • S. Katamine
    • 2
  • S. Hino
    • 1
  1. 1. Department of Virology, Faculty of Medicine, Tottori University, Yonago, JapanJP
  2. 2. Department of Bacteriology, School of Medicine, Nagasaki University, Nagasaki, JapanJP

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