Advertisement

Detection of vaccine-like strains of lumpy skin disease virus in outbreaks in Russia in 2017

  • Aleksandr Kononov
  • Olga Byadovskaya
  • Svetlana Kononova
  • Roman Yashin
  • Nikolay Zinyakov
  • Vladimir Mischenko
  • Nataliya Perevozchikova
  • Alexander SpryginEmail author
Original Article
  • 64 Downloads

Abstract

Lumpy skin disease (LSD) has affected many regions of Russia since its first occurrence in 2015. The most devastating year for Russia was 2016, when the virus resurged following a modified stamping-out campaign, causing 313 outbreaks in 16 regions. To avoid unwanted adverse reactions following the use of live attenuated vaccines against LSD virus (LSDV), sheeppox-based vaccines were administered during vaccination campaigns. As a result, LSD was successfully contained in all Russian regions in 2017. In the same year, however, LSD emerged anew in a few regions of the Privolzhsky Federal District of Russia along the northern border of Kazakhstan, which then necessitated vaccinating cattle with a live attenuated LSDV vaccine. Although live attenuated LSDV vaccines are prohibited in Russia, several vaccine-like LSDV strains were identified in the 2017 outbreaks, including commercial farms and backyard animals exhibiting clinical signs consistent with those of field LSDV strains. Sequence alignments of three vaccine-like LSDV strains showed clear similarity to the corresponding RPO30 and GPCR gene sequences of commercial attenuated viruses. How vaccine-like strains spread into Russian cattle remains to be clarified.

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Ethical approval

This study does not contain any subjects with human participants or animals performed by the authors.

References

  1. 1.
    Tageldin M, Wallace D, Gerdes G, Putterill J, Greyling R, Phosiwa M, Al Busaidy R, Al Ismaaily S (2014) Lumpy skin disease of cattle: an emerging problem in the Sultanate of Oman. Trop Anim Health Prod 46(1):241–246.  https://doi.org/10.1007/s11250-013-0483-3 CrossRefGoogle Scholar
  2. 2.
    Şevik M, Doğan M (2016) Epidemiological and molecular studies on lumpy skin disease outbreaks in Turkey during 2014–2015. Transbound Emerg Dis 64(4):1268–1279.  https://doi.org/10.1111/tbed.12501 Google Scholar
  3. 3.
    Coetzer JAW (2004) Lumpy skin disease. In: Coetzer JAW, Tustin RC (eds) Infectious diseases of livestock, vol 2. Oxford University Press Southern Africa, Cape Town, pp 1268–1276Google Scholar
  4. 4.
    Tulman ER, Afonso CL, Lu Z, Zsak L, Kutish GF, Rock DL (2001) Genome of lumpy skin disease virus. J Virol 15:7122–7130.  https://doi.org/10.1128/jvi.75.15.7122-7130.2001 CrossRefGoogle Scholar
  5. 5.
    El-Tholoth M, El-Kenawy AA (2016) G-protein-coupled chemokine receptor gene in lumpy skin disease virus isolates from cattle and water buffalo (Bubalus bubalis) in Egypt. Transbound Emerg Dis 63:e288–e295.  https://doi.org/10.1111/tbed.12344 CrossRefGoogle Scholar
  6. 6.
    Tuppurainen ES, Venter EH, Shisler JL, Gari G, Mekonnen GA, Juleff N, Lyons NA, De Clercq K, Upton C, Bowden TR, Babiuk S, Babiuk LA (2017) Capripoxvirus diseases: current status and opportunities for control. Transbound Emerg Dis 64:729–745.  https://doi.org/10.1111/tbed.12444 CrossRefGoogle Scholar
  7. 7.
    Davies FG (1991) Lumpy skin disease of cattle: a growing problem in Africa and the Near East. World Anim Rev 68:37–42Google Scholar
  8. 8.
    Weiss KE (1968) Lumpy skin disease virus. Virol Monogr 3:111–131CrossRefGoogle Scholar
  9. 9.
    Vorster JH, Mapham PH (2008) Lumpy skin disease. Livestock health and production Review. Jaargang 10(1):16–21Google Scholar
  10. 10.
    Kahana-Sutin E, Klement E, Lensky I, Gottlieb Y (2017) High relative abundance of the stable fly Stomoxys calcitrans is associated with lumpy skin disease outbreaks in Israeli dairy farms. Med Vet Entomol 31:150–160CrossRefGoogle Scholar
  11. 11.
    Tuppurainen ES, Pearson CR, Bachanek-Bankowska K, Knowles NJ, Amareen S, Frost L, Henstock MR, Lamien CE, Diallo A, Mertens PP (2014) Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus. Antiviral Res 109:1–6CrossRefGoogle Scholar
  12. 12.
    Kitching RP (2003) Vaccines for lumpy skin disease, sheep pox and goat pox. Dev Biol 114:161–167Google Scholar
  13. 13.
    Tasioudi KE, Antoniou SE, Iliadou P, Sachpatzidis A, Plevraki E, Agianniotaki EI, Fouki C, Mangana-Vougiouka O, Chondrokouki E, Dile C (2015) Emergence of lumpy skin disease in Greece, 2015. Transbound Emerg Dis 63:260–265.  https://doi.org/10.1111/tbed.12497 CrossRefGoogle Scholar
  14. 14.
    Zeynalova S, Asadov K et al (2016) Epizootology and molecular diagnosis of lumpy skin disease among livestock in Azerbaijan. Front Microbiol 7:1022.  https://doi.org/10.3389/fmicb.2016.01022 CrossRefGoogle Scholar
  15. 15.
    Wainwright S, El Idrissi A, Mattioli R, Tibbo M, Njeumi F, Raizman E (2013) Emergence of lumpy skin disease in the Eastern Mediterranean Basin countries. FAO Empres Watch 29:1–6Google Scholar
  16. 16.
    Biryuchenkova M, Timina A, Znyakov N, Tscherbakov A (2015) The results of testing for lumpy skin disease in Dagestan and Chechnya republics: the first confirmation in the Russian Federaion. Vet Sci Today 4:43–45 (In Russian) Google Scholar
  17. 17.
    Sprygin A, Artyuchova E, Babin YU, Prutnikov P, Kostrova E, Byadovskaya O, Kononov A (2018) Epidemiological characterization of lumpy skin disease outbreaks in Russia in 2016. Transbound Emerg Dis 65(6):1514–1521.  https://doi.org/10.1111/tbed.12889 CrossRefGoogle Scholar
  18. 18.
    Sprygin A, Pestova YA, Prutnikov P, Kononov A (2018) Detection of vaccine lumpy skin disease virus in cattle and Musca domestica L. flies in an outbreak of lumpy skin disease in Russia in 2017. Transbound Emerg Dis. 65(5):1137–1144.  https://doi.org/10.1111/tbed.12897 CrossRefGoogle Scholar
  19. 19.
    Pestova Y, Artyukhova E, Kostrova E, Shumoliva I, Kononov A, Sprygin A (2018) Real time PCR for the detection of field isolates of lumpy skin disease virus in clinical samples from cattle. Sel’skokhozyaistvennaya Biol 53:422–429.  https://doi.org/10.15389/agrobiology.2017.6.///eng CrossRefGoogle Scholar
  20. 20.
    Sprygin A, Pestova Y, Kostrova E, Kononova S, Byadovskaya O, Zhbanova T, Kononov A (2019) One-run real time PCR assays for the detection of capripoxviruses, field isolates and vaccine strains of lumpy skin disease virus. Sel’skokhozyaistvennaya Biol.  https://doi.org/10.15389/agrobiology.2019.2.///eng Google Scholar
  21. 21.
    Agianniotaki EI, Chaintoutis SC, Haegeman A, Tasioudi KE, De Leeuw I, Katsoulos PD, Sachpatzidis A, De Clercq K, Alexandropoulos T, Polizopoulou ZS, Chondrokouki ED, Dovas CI (2017) Development and validation of a TaqMan probe-based real-time PCR method for the differentiation of wild type lumpy skin disease virus from vaccine virus strains. J Virol Methods 249:48–57.  https://doi.org/10.1016/j.jviromet.2017.08.011 CrossRefGoogle Scholar
  22. 22.
    Lamien CE, Lelenta M, Goger W, Silber R, Tuppurainen E, Matijevic M, Luckins AG, Diallo A (2011) Real time PCR method for simultaneous detection, quantitation and differentiation of capripoxviruses. J Virol Methods 171:134–140CrossRefGoogle Scholar
  23. 23.
    Le Goff C, Lamien CE, Fakhfakh E et al (2009) Capripoxvirus G-protein-coupled chemokine receptor: a host-range gene suitable for virus animal origin discrimination. J Gen Virol 90:1967–1977CrossRefGoogle Scholar
  24. 24.
    Sprygin A, Babin Y, Pestova Y, Kononova S, Byadovskaya O, Kononov A (2019) Complete genome sequence of the lumpy skin disease virus recovered from the first outbreak in the Northern Caucasus region of Russia in 2015. Microbiol Resour Announc 8(8):e01733-18.  https://doi.org/10.1128/MRA.01733-18 CrossRefGoogle Scholar
  25. 25.
    Bedeković T, Šimić I, Krešić N, Lojkić I (2018) Detection of lumpy skin disease virus in skin lesions, blood, nasal swabs and milk following preventive vaccination. Transbound Emerg Dis 65(2):491–496CrossRefGoogle Scholar
  26. 26.
    Sprygin A, Babin Y, Pestova Y, Kononova S, Wallace DB, Van Schalkwyk A, Byadovskaya O, Diev V, Lozovoy D, Kononov A (2018) Analysis and insights into recombination signals in lumpy skin disease virus recovered in the field. PLoS One 13(12):e0207480.  https://doi.org/10.1371/journal.pone.0207480 (eCollection 2018) CrossRefGoogle Scholar
  27. 27.
    Chihota CM, Rennie LF, Kitching RP, Mellor PS (2003) Attempted mechanical transmission of lumpy skin disease virus by biting insects. Med Vet Entomol 17:294–300CrossRefGoogle Scholar
  28. 28.
    Chihota CM, Rennie LF, Kitching RP, Mellor PS (2001) Mechanical transmission of lumpy skin disease virus by Aedes aegypti (Diptera: Culicidae). Epidemiol Infect 126:317–321.  https://doi.org/10.1017/S0950268801005179 CrossRefGoogle Scholar
  29. 29.
    Kolcov A (2018) Molecular-genetic and biological characterization of lumpy skin disease virus isolated in Saratov region of Russia in 2017. In: Proceedings of 12th annual meeting EPIZONE; 2018 Aug 27–30; Vienna, AustriaGoogle Scholar
  30. 30.
    Bull J, Smithson M, Nuismer S (2018) Transmissible viral vaccines. Trends Microbiol 26(1):6–15.  https://doi.org/10.1016/j.tim.2017.09.007 CrossRefGoogle Scholar
  31. 31.
    Klement E, Broglia A, Antoniou S, Tsiamadis V, Plevraki E, Petrović T, Polaček V, Debeljak Z, Miteva A, Alexandrov T, Marojevic D, Pite L, Kondratenko V, Atanasov Z, Gubbins S, Stegeman A, Abrahantes J (2018) Neethling vaccine proved highly effective in controlling lumpy skin disease epidemics in the Balkans. Prev Vet Med.  https://doi.org/10.1016/j.prevetmed.2018.12.001 Google Scholar
  32. 32.
    Van Rooyen P, Munz K, Weiss K (1969) The optimal conditions for the multiplication of Neethling-Type lumpy skin disease virus in embryonated eggs. Onderstepoort J Vet Res 36:165–174Google Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Federal Center for Animal HealthVladimirRussia

Personalised recommendations