Archives of Virology

, Volume 164, Issue 5, pp 1427–1432 | Cite as

High genetic diversity of noroviruses in children from a community-based study in Rio de Janeiro, Brazil, 2014-2018

  • Carina Pacheco CantelliEmail author
  • Marcelle Figueira Marques da Silva
  • Tulio Machado Fumian
  • Denise Cotrim da Cunha
  • Juliana da Silva Ribeiro de Andrade
  • Fábio Correia Malta
  • Sérgio da Silva e Mouta Junior
  • Alexandre Madi Fialho
  • Marcia Terezinha Baroni de Moraes
  • Patricia Brasil
  • Marize Pereira Miagostovich
  • José Paulo Gagliardi Leite
Brief Report


We report on the occurrence and diversity of noroviruses in children (younger than 5 years old of age) from a low-income urban area in Rio de Janeiro, Brazil. Sixty-one stool specimens collected from children between 1 and 4 years old with acute diarrhoeic episodes (ADE) and non-ADE were investigated. RT-qPCR and sequencing of PCR products after conventional RT-PCR analysis were performed. Noroviruses were detected in 29 (47.5%) samples: 21 (46.7%) from cases with ADE and 8 (50%) from non-ADE cases. Molecular characterization showed 10 different genotypes circulating in this community between November 2014 and April 2018.



We would like to thank Miriã Alves Gonçalves Trindade for her help with the collection of specimens and clinical data. We would like to thank Rosane Maria Santos de Assis, Erica Louro da Fonseca, Greice Maria Silva da Conceição and Darcy Akemi Hokama for laboratorial and technical support. Special thanks to Dr. David Brown for the revision of this manuscript.


This study was funded by “The Oswaldo Cruz Institute/Fiocruz”, “The Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro” (FAPERJ E-26/202.968/2015), and “The National Council for Scientific and Technological Development” (CNPq 424376/2016-4).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Ethics Committee of Fiocruz (CEP 311/06; CEP 688.566/14).

Informed consent

Informed consent was obtained from the parent or guardian of each child included in this study.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Carina Pacheco Cantelli
    • 1
    • 2
    Email author
  • Marcelle Figueira Marques da Silva
    • 3
  • Tulio Machado Fumian
    • 2
  • Denise Cotrim da Cunha
    • 4
  • Juliana da Silva Ribeiro de Andrade
    • 2
  • Fábio Correia Malta
    • 2
  • Sérgio da Silva e Mouta Junior
    • 2
  • Alexandre Madi Fialho
    • 2
  • Marcia Terezinha Baroni de Moraes
    • 2
  • Patricia Brasil
    • 5
  • Marize Pereira Miagostovich
    • 2
  • José Paulo Gagliardi Leite
    • 2
  1. 1.Technology Institute for Immunobiologicals/Bio-ManguinhosRio de JaneiroBrazil
  2. 2.Laboratory of Comparative and Environmental VirologyOswaldo Cruz InstituteRio de JaneiroBrazil
  3. 3.Tropical Pathology and Public Health InstituteFederal University of GoiásGoiâniaBrazil
  4. 4.Sérgio Arouca, Public Health National SchoolRio de JaneiroBrazil
  5. 5.Evandro Chagas National Institute of Infectious DiseasesRio de JaneiroBrazil

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