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Archives of Virology

, Volume 164, Issue 2, pp 607–612 | Cite as

Molecular evolutionary and antigenic characteristics of newly isolated H9N2 avian influenza viruses in Guangdong province, China

  • Jipei Zhang
  • Huiji Wu
  • Yishan Zhang
  • Mengrui Cao
  • Morgan Brisse
  • Wanjun Zhu
  • Rongxu Li
  • Minfang Liu
  • Mingsheng Cai
  • Jianhong ChenEmail author
  • Jidang ChenEmail author
Brief Report

Abstract

Four new H9N2 avian influenza viruses (AIVs) were isolated from domestic birds in Guangdong between December 2015 and April 2016. Nucleotide sequence comparisons indicated that most of the internal genes of these four strains were highly similar to those of human H7N9 viruses. Amino acid substitutions and deletions found in the HA and NA proteins indicated that all four of these new isolates may have an enhanced ability to infect humans and other mammals. A cross-hemagglutinin-inhibition assay, conducted with two vaccine strains that are broadly used in China, suggested that antisera against vaccine candidates could not provide complete inhibition of the new isolates.

Notes

Funding

This study was supported by the Young Scientists Fund of National Natural Science Foundation of China (NSFC) (31800141), Natural Science Foundation of Guangdong Province, China (2017A030310573), High-Level Talent Start-Up Research Project of the Foshan University (Gg040967), National Natural Science Foundation of China (31400150).

Compliance with ethical standards

Ethics approval and consent to participate

The swab sampling and experiments were approved by the Institutional Animal Care and Use Committee of Guangzhou Medical University (2015-108).

Competing interests

The authors declare that they have no competing interests.

Supplementary material

705_2018_4103_MOESM1_ESM.docx (3.9 mb)
Supplementary material 1 (DOCX 4034 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Life Science and EngineeringFoshan UniversityFoshanPeople’s Republic of China
  2. 2.College of Veterinary MedicineUniversity of MinnesotaSaint PaulUSA
  3. 3.Department of Pathogenic Biology and Immunology, Sino-French Hoffmann Institute, School of Basic Medical ScienceGuangzhou Medical UniversityGuangzhouPeople’s Republic of China

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