Archives of Virology

, Volume 163, Issue 11, pp 3141–3148 | Cite as

Comparative genomics of human rubulavirus 2

  • Maja ŠantakEmail author
  • Gordana Mlinarić-Galinović
  • Tatjana Vilibić-Čavlek
  • Irena Tabain
Brief Report


Although human rubulavirus 2 (HPIV2) is an important respiratory pathogen, little is known about its molecular epidemiology. We performed a comparative analysis of the full-length genomes of fourteen HPIV2 isolates belonging to different genotypes. Additionally, evolutionary analyses (phylogenetic reconstruction, sequence identity, detection of recombination and adaptive evolution) were conducted. Our study presents a systematic comparative genetic analysis that complements prior analyses and utilizes full-length HPIV2 genomes to provide a basis for future work on the clinical significance, molecular variation and conservation, and evolution of HPIV2.



This work has been supported by the Croatian Science Foundation under the project number 6255 and by the grant “Strengthening the capacity of CerVirVac for research in virus immunology and vaccinology“, KK., awarded to the Scientific Centre of Excellence for Virus Immunology and Vaccines and co-financed by the European Regional Development Fund.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Supplementary material

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Supplementary material 1 (TIFF 99 kb)
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Supplementary material 2 (TIFF 386 kb)
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Supplementary material 3 (DOCX 14 kb)
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Supplementary material 4 (DOCX 20 kb)


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Maja Šantak
    • 1
    Email author
  • Gordana Mlinarić-Galinović
    • 2
  • Tatjana Vilibić-Čavlek
    • 2
    • 3
  • Irena Tabain
    • 3
  1. 1.Centre for Research and Knowledge Transfer in BiotechnologyUniversity of ZagrebZagrebCroatia
  2. 2.School of MedicineUniversity of ZagrebZagrebCroatia
  3. 3.Croatian National Institute of Public HealthZagrebCroatia

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