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Archives of Virology

, Volume 163, Issue 11, pp 3015–3022 | Cite as

Histamine contributes to severe pneumonia in pigs infected with 2009 pandemic H1N1 influenza virus

  • Yunyueng Jang
  • Myongha Jin
  • Sang Heui Seo
Original Article

Abstract

Histamine is a biogenic amine that influences many immune cells. In this study, we investigated the effect of histamine on the pathogenesis of 2009 pandemic H1N1 influenza virus in pigs. Histamine was not detected in the tracheal tissues of infected pigs, and no difference was found in the pathological damage found in infected pigs with and without treatment with a histamine antagonist. Lung tissues from untreated infected pigs showed severe interstitial pneumonia with accumulation of histamine, in contrast to those from infected pigs that were treated with the histamine antagonist. The expression of inflammatory cytokines was much higher in the lungs of untreated infected pigs than in infected pigs treated with the histamine antagonist. These data suggest that histamine necessary for the development of the severe pneumonia in infected pigs.

Notes

Acknowledgements

This work was funded by the Basic Science Research Program through the National Research Foundation of Korea (NRF) from the Ministry of Science and Technology (2015R1A2A2A01003943).

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Consent for publication

All authors consent to publication.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Laboratory of Influenza Research, College of Veterinary MedicineChungnam National UniversityDaejeonRepublic of Korea
  2. 2.Institute of Influenza Virus, College of Veterinary MedicineChungnam National UniversityDaejeonRepublic of Korea

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