Genetic characterization of a new astrovirus in goslings suffering from gout
Since early 2016, the Chinese goose industry has experienced severe outbreaks of gout; however, the etiological factor of the disease is still unclear. Here, we investigated the possible involvement of viral infection in the disease. Using sequence-independent PCR amplification, astrovirus sequences were generated from a gout case. Full-length genomic sequencing and sequence analysis of three goose astrovirus (GoAstV) strains revealed that they belong to a new avastrovirus most closely related to viruses classified within species Avastrovirus 3. The GoAstV was detected in 16/16 gout cases collected from two provinces, supporting a pathogenic role for the new avastrovirus.
This study was funded by the China Agriculture Research System (CARS-42-16).
Compliance with ethical standards
Conflict of interest
Meiling Jin declares that she has no conflict of interest. Xiaoyan Wang declares that she has no conflict of interest. Ning Kang declares that he has no conflict of interest. Ning Liu declares that she has no conflict of interest. Dabing Zhang declares that he has no conflict of interest.
All procedures involving sample collection from goslings were approved by the Animal Welfare and Ethical Censor Committee at China Agricultural University and Beijing Administration Committee of Laboratory Animals (Approval ID SYXK [Jing] 2015–0028).
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