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Archives of Virology

, Volume 163, Issue 10, pp 2711–2718 | Cite as

Association of CXCR2 genotype variations with HCV clearance in a Chinese population

  • Feng Zang
  • Ming Yue
  • Lingyun Zhuo
  • Jingjing Wu
  • Mei Liu
  • Yinan Yao
  • Jie Wang
  • Yue Feng
  • Xueshan Xia
  • Peng Huang
  • Rongbin Yu
Original Article

Abstract

Chemokines are known to play a vital role in guiding and regulating the immune response to viral infections. The chemokine CXC subfamily is a major subfamily in the chemokine family. Outcomes of hepatitis C virus (HCV) infection, as well as the response to treatment, depend on virus and host factors. Here we recruited chronic hepatitis C (CHC) patients to perform an association study between three single nucleotide polymorphisms (SNPs) (CXCR2 rs1126579, CXCL10 rs8878 and CXCL10 rs3921) and HCV infection outcomes and treatment responses among a Chinese population, using primarily a TaqMan assay. Multivariate logistic regression analysis was performed to identify the influencing factors on HCV infection outcome and treatment response. The results showed that subjects with the CXCR2 rs1126579 TT genotype had a significantly increased possibility of HCV spontaneous clearance (Dominant model: adjusted OR = 1.32, 95% CI = 1.06-1.64; P = 0.013). Additionally, CHC patients carrying the CXCR2 rs1126579 TT genotype were also more likely to achieve a sustained virological response (SVR) (Dominant model: adjusted OR = 0.49, 95% CI = 0.29-0.84; P = 0.010). We also established a predictive model for HCV treatment response including the CXCR2 rs1126579 SNP status, albumin (ALB) levels and baseline HCV RNA levels, which produced an area under the curve (AUC) of about 0.660. These findings highlight that variant CXCR2 rs1126579 genotypes are associated with HCV clearance within the Chinese population.

Notes

Author contributions

FZ, PH and RY participated in the design of the study. FZ and MY carried out the surveys and experiments. FZ performed the statistical analysis. LZ, JW, ML and YY contributed materials and analysis tools. FZ wrote the paper. All authors read and approved the final manuscript.

Funding

The current study was supported in part by National Natural Science Foundation of China (No. 81473029, 81703273, 81502853, 81473028), Natural Science Foundation of Jiangsu Province (BK2017041691, BK20151026), the Science and Technology Development Fund Key Project of Nanjing Medical University (2016NJMUZD012), Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

Compliance with ethical standards

Conflicts of interest

The authors declare no conflict of interest.

Ethical approval

This study was approved by the Ethics Committee of Nanjing Medical University.

Informed consent

All subjects were provided the voluntary informed consent to participate in the study.

Supplementary material

705_2018_3872_MOESM1_ESM.doc (36 kb)
Supplementary material 1 (DOC 35 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Epidemiology and Biostatistics, School of Public Health, Key Laboratory of Infectious DiseasesNanjing Medical UniversityNanjingChina
  2. 2.Department of Infectious DiseasesThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  3. 3.Department of Basic and Community Nursing, School of NursingNanjing Medical UniversityNanjingChina
  4. 4.Faculty of Life Science and TechnologyKunming University of Science and TechnologyKunmingChina

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