Genetic diversity of human papillomavirus types 35, 45 and 58 in cervical cancer in Brazil
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In Brazil, most studies of intra-type variants of human papillomavirus (HPV) have focused on HPV16 and HPV18, but other high-risk HPV types have not been studied. Here, we report the prevalence of lineages and variants of HPV35, HPV45 and HPV58 in cervical cancers from the Amazonian and Southeast Brazilian regions. The most frequent sublineages were A1 for HPV35, B2 for HPV45, and A2 for HPV58. The Southeast region had a higher frequency of the B2 sublineage of HPV45, and for HPV35, the genetic and nucleotide sequence diversity were higher in the Southeast region, suggesting that regional factors are influencing the diversity and lineage prevalence.
KeywordsCervical cancer Papillomavirus HPV35 HPV45 HPV58 HPV diversity
We want to thank the physicians who collected the tumor biopsies. This work was supported by the National Institute for Cancer Control (INCT do Cancer: http://www.inct-cancer-control.com.br/); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Grants 573806/2008-0, 484005/2013-8 and 305873/2014-8; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) Grant E26/170.026/2008; Ministry of Health – Brazil; and Pan-American Health Organization (PAHO).
Compliance with ethical standards
All procedures were approved by the Research Ethics Committees of the Instituto Nacional de Câncer (CAAE 53398416.0.0000.5274) and the Hospital Ophir Loyola (CAAE 03288212.0.1001.0018).
All patients signed an informed consent form.
This article does not contain any studies with animals.
Conflict of interest
The authors declare no conflict of interest.
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