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Archives of Virology

, Volume 162, Issue 9, pp 2539–2551 | Cite as

Flavonoids: promising natural compounds against viral infections

  • Hovakim ZakaryanEmail author
  • Erik Arabyan
  • Adrian Oo
  • Keivan Zandi
Review

Abstract

Flavonoids are widely distributed as secondary metabolites produced by plants and play important roles in plant physiology, having a variety of potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activity. Different flavonoids have been investigated for their potential antiviral activities and several of them exhibited significant antiviral properties in in vitro and even in vivo studies. This review summarizes the evidence for antiviral activity of different flavonoids, highlighting, where investigated, the cellular and molecular mechanisms of action on viruses. We also present future perspectives on therapeutic applications of flavonoids against viral infections.

Notes

Acknowledgements

The authors acknowledge all reviewers whose detailed comments improved the review and apologize to those authors whose contribution to flavonoids antiviral research may have been inadvertently missed.

Compliance with ethical standards

Ethical standards

This study is supported by the RA MES State Committee of Science, in the frames of the research projects 15RF-081 and 16YR-1F064. All authors declare that they have no conflict of interest. This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag Wien 2017

Authors and Affiliations

  • Hovakim Zakaryan
    • 1
    Email author
  • Erik Arabyan
    • 1
  • Adrian Oo
    • 2
  • Keivan Zandi
    • 2
    • 3
  1. 1.Group of Antiviral Defense MechanismsInstitute of Molecular Biology of NAS RAYerevanArmenia
  2. 2.Department of Medical Microbiology, Faculty of Medicine, Tropical Infectious Disease Research and Education Center (TIDREC)University of MalayaKuala LumpurMalaysia
  3. 3.Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of MedicineEmory UniversityAtlantaUSA

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