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Archives of Virology

, Volume 161, Issue 12, pp 3509–3514 | Cite as

Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro

  • Manik Ghosh
  • Andrea Civra
  • Massimo Rittà
  • Valeria Cagno
  • Siva Ganesh Mavuduru
  • Preeti Awasthi
  • David Lembo
  • Manuela DonalisioEmail author
Brief Report

Abstract

Ficus religiosa extracts have been used in traditional Indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. The aim of this study was to investigate the antiviral activity of F. religiosa extracts against herpes simplex virus type 2 (HSV-2), the main causative agent of genital ulcers and sores. Water and chloroform bark extracts were the most active against HSV-2, and also against an acyclovir-resistant strain. We demonstrate that the water extract has a direct virus-inactivating activity. By contrast, the chloroform extract inhibits viral attachment and entry and limits the production of viral progeny.

Keywords

HSV-2 Antiviral Plant extract Ficus religiosa 

Notes

Acknowledgments

This study was supported by a donation from Silvana Legnani.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

705_2016_3032_MOESM1_ESM.docx (13 kb)
Supplementary material 1 (DOCX 13 kb)

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  1. 1.Department of Pharmaceutical Sciences and TechnologyBirla Institute of TechnologyRanchiIndia
  2. 2.Department of Clinical and Biological Sciences, S. Luigi Gonzaga HospitalUniversity of TorinoTurinItaly

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