Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection
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Rabies virus infection is a major public health concern because of its wide host-interference spectrum and nearly 100 % lethality. However, the interactions between host and virus remain unclear. To decipher the authentic response in the central nervous system after rabies virus infection, a dynamic analysis of brain proteome alteration was performed. In this study, 104 significantly differentially expressed proteins were identified, and intermediate filament, interferon-inducible GTPases, and leucine-rich repeat-containing protein 16C were the three outstanding groups among these proteins. Interferon-inducible GTPases were prominent because of their strong upregulation. Moreover, quantitative real-time PCR showed distinct upregulation of interferon-inducible GTPases at the level of transcription. Several studies have shown that interferon-inducible GTPases are involved in many biological processes, such as viral infection, endoplasmic reticulum stress response, and autophagy. These findings indicate that interferon-inducible GTPases are likely to be a potential target involved in rabies pathogenesis or the antiviral process.
KeywordsGlial Fibrillary Acidic Protein Rabies Rabies Virus Infection Tetraethylammonium Bromide Challenge Virus Standard
This work was supported in part by the National Natural Science Foundation of China (No. 31472175, 81171555), the National Natural Science Foundation for Young Scholars (No. 31101791), China Postdoctoral Science Foundation Grant (No. 2014T71003 and 2012M512108) and the Science and Technology Development Plan of Jilin Province (No. 20140520174JH).
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Conflict of interest
The authors have declared that no competing interests exist.
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