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Archives of Virology

, Volume 160, Issue 8, pp 2087–2091 | Cite as

Delayed-onset enzootic bovine leukosis possibly caused by superinfection with bovine leukemia virus mutated in the pol gene

  • Tadaaki Watanabe
  • Emi Inoue
  • Hiroshi Mori
  • Yoshiaki Osawa
  • Katsunori OkazakiEmail author
Brief Report

Abstract

Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis (EBL), to which animals are most susceptible at 4–8 years of age. In this study, we examined tumor cells associated with EBL in an 18-year-old cow to reveal that the cells carried at least two different copies of the virus, one of which was predicted to encode a reverse transcriptase (RT) lacking ribonuclease H activity and no integrase. Such a deficient enzyme may exhibit a dominant negative effect on the wild-type RT and cause insufficient viral replication, resulting in delayed tumor development in this cow.

Keywords

Long Terminal Repeat Bovine Leukemia Virus Moloney Murine Leukemia Virus Reverse Transcriptase Defective Virus Enzootic Bovine Leukosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was partly supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We thank the workers at the Meat Inspection Office for their extensive help in collecting the samples.

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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Tadaaki Watanabe
    • 1
  • Emi Inoue
    • 1
  • Hiroshi Mori
    • 1
  • Yoshiaki Osawa
    • 1
  • Katsunori Okazaki
    • 1
    Email author
  1. 1.Laboratory of Microbiology and Immunology, Faculty of Pharmaceutical SciencesHealth Sciences University of HokkaidoIshikari-TobetsuJapan

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