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Archives of Virology

, Volume 160, Issue 5, pp 1189–1195 | Cite as

First genome sequence of St. Louis encephalitis virus (SLEV) isolated from a human in Brazil

  • Danila Vedovello
  • Betânia Paiva Drumond
  • Rafael Elias Marques
  • Leila Sabrina Ullmann
  • Eliane Aparecida Fávaro
  • Ana Carolina Bernardes Terzian
  • Luiz Tadeu Moraes Figueiredo
  • Mauro Martins Teixeira
  • João Pessoa Araújo Junior
  • Maurício Lacerda NogueiraEmail author
Original Article

Abstract

St. Louis encephalitis virus (SLEV), a member of the family Flaviviridae, genus Flavivirus, is a causative agent of encephalitis in the Americas. In Brazil, sporadic cases of SLEV infection have been reported since 1953, but the first outbreak of SLEV in Brazil was identified only in 2007, concomitant with an outbreak of dengue virus (DENV) serotype 3. This finding, along with other reports, indicates that SLEV circulation in Brazil is largely unknown, and there may be epidemiological implications of the co-circulation of SLEV, DENV and other flaviviruses in Brazil. Here, we describe the first complete genome sequence of an SLEV strain isolated from a human patient in Brazil, strain BeH 355964. Phylogenetic analysis was performed to determine the genotype of BeH 355964 using the full-length genome and envelope (E) gene sequences separately. Both analyses showed that BeH 355964 could be classified as genotype V. Although the number of single gene sequences available is greater (such as for the E gene), the phylogenetic tree based on the complete genome sequence was better supported and provided further information about the virus.

Keywords

West Nile Virus Dengue Virus Japanese Encephalitis Virus DENV Infection Japanese Encephalitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Financial support to MLN by FAPESP (Grant No. 2012/11733-6) CAPES and CNPq.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

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Supplementary material 1 (doc 81 kb)
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Supplementary material 2 (doc 286 kb)
705_2015_2378_MOESM3_ESM.docx (16 kb)
Supplementary material 3 (docx 15 kb)
705_2015_2378_MOESM4_ESM.docx (25 kb)
Supplementary material 4 (docx 24 kb)

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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Danila Vedovello
    • 1
  • Betânia Paiva Drumond
    • 2
  • Rafael Elias Marques
    • 3
  • Leila Sabrina Ullmann
    • 4
  • Eliane Aparecida Fávaro
    • 1
  • Ana Carolina Bernardes Terzian
    • 1
  • Luiz Tadeu Moraes Figueiredo
    • 5
  • Mauro Martins Teixeira
    • 3
  • João Pessoa Araújo Junior
    • 4
  • Maurício Lacerda Nogueira
    • 1
    Email author
  1. 1.Faculdade de Medicina de São José do Rio Preto (FAMERP)São José do Rio PretoBrazil
  2. 2.Universidade Federal de Juiz de ForaJuiz de ForaBrazil
  3. 3.Universidade Federal de Minas GeraisBelo HorizonteBrazil
  4. 4.Universidade Estadual PaulistaBotucatuBrazil
  5. 5.Universidade de São PauloRibeirão PretoBrazil

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