Archives of Virology

, Volume 160, Issue 2, pp 441–445 | Cite as

Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma

  • Lu Han
  • Lingling Sun
  • Zhenzhen Zhao
  • Yan Chao
  • Zhifu Sun
  • Hui Li
  • Bing LuoEmail author
Brief Report


To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin’s lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.


Lymphoma Mature Protein Signal Peptide Region Lytic Phase Throat Wash 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Grant sponsor: Specialized Research Fund for the Doctoral Program of Higher Education; Grant number: 20133706110001; Grant sponsor: Natural Science Foundation of Shandong Province; Grant number: ZR2011CM016. Grant sponsor: Science and Technology of Qingdao City, China; Grant number: 13-1-3-50-jch.


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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Lu Han
    • 1
  • Lingling Sun
    • 2
  • Zhenzhen Zhao
    • 1
  • Yan Chao
    • 3
  • Zhifu Sun
    • 4
  • Hui Li
    • 5
  • Bing Luo
    • 1
    Email author
  1. 1.Department of Medical MicrobiologyQingdao University Medical CollegeQingdaoChina
  2. 2.Department of PathologyAffiliated Hospital of Qingdao University Medical CollegeQingdaoChina
  3. 3.Department of Blood TransfusionThe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina
  4. 4.Department of Health Sciences ResearchMayo ClinicRochesterUSA
  5. 5.Department of Clinical LaboratoryThe Affiliated Hospital of Qingdao University Medical CollegeQingdaoChina

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