Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma
To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin’s lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.
KeywordsLymphoma Mature Protein Signal Peptide Region Lytic Phase Throat Wash
Grant sponsor: Specialized Research Fund for the Doctoral Program of Higher Education; Grant number: 20133706110001; Grant sponsor: Natural Science Foundation of Shandong Province; Grant number: ZR2011CM016. Grant sponsor: Science and Technology of Qingdao City, China; Grant number: 13-1-3-50-jch.
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