Archives of Virology

, Volume 159, Issue 10, pp 2819–2821 | Cite as

Genome sequence of a pathogenic isolate of monkey B virus (species Macacine herpesvirus 1)

  • Kazutaka Ohsawa
  • Darla Black
  • Makiko Ohsawa
  • R. EberleEmail author
Annotated Sequence Record


The only genome sequence for monkey B virus (BV; species Macacine herpesvirus 1) is that of an attenuated vaccine strain originally isolated from a rhesus monkey (BVrh). Here we report the genome sequence of a virulent BV strain isolated from a cynomolgus macaque (BVcy). The overall genome organization is the same, although sequence differences exist. The greatest sequence divergence is located in non-coding areas of the long and short repeat regions. Like BVrh, BVcy has duplicated Ori elements and lacks an ORF corresponding to the γ34.5 gene of herpes simplex virus. Nine of ten miRNAs and the majority of ORFs are conserved between BVrh and BVcy. The most divergent genes are several membrane-associated proteins and those encoding immediate early proteins.


Rhesus Macaque Splice Junction Cynomolgus Macaque Macaque Species Primate Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was partially supported by grants P40 OD010988 and P40 OD010431 from the National Institutes of Health (DB, RE) and Grant-in Aid for Scientific Research B #19300148 from the Ministry of Education, Culture, Sport, Science and Technology of Japan (KO, MO).

Supplementary material

705_2014_2130_MOESM1_ESM.xls (158 kb)
Supplementary material 1 (XLS 158 kb)
705_2014_2130_MOESM2_ESM.txt (280 kb)
Supplementary material 2 (TXT 279 kb)


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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Kazutaka Ohsawa
    • 2
  • Darla Black
    • 1
  • Makiko Ohsawa
    • 2
  • R. Eberle
    • 1
    Email author
  1. 1.Department of Veterinary Pathobiology, Center for Veterinary Health SciencesOklahoma State UniversityStillwaterUSA
  2. 2.Division of Comparative Medicine, Center for Frontier Life SciencesNagasaki UniversityNagasakiJapan

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