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Archives of Virology

, Volume 159, Issue 8, pp 2141–2144 | Cite as

Allelic variants of PRNP in 16 Chinese local sheep breeds

  • Zouran Lan
  • Jinming Li
  • Chengyou Sun
  • Yutian Liu
  • Yonggang Zhao
  • Tianying Chi
  • Xiaojing Yu
  • Fangfang Song
  • Zhiliang WangEmail author
Brief Report

Abstract

Here, polymorphisms of the ovine prion protein gene were analyzed in 486 Chinese sheep from 16 main local breeds. Polymorphisms R or H at codons 154 and four polymorphisms at codon 171 encoding Q, R, H, or K were identified. The A/V polymorphism at codon 136 was not observed, and all sheep were homozygous for A at this position. In addition, ten polymorphisms at codons 21, 101, 112, 127, 138, 141, 143, 146, 153 and 189 were detected. The predominant Q allele occurred at codon 171, with a high frequency of 88.68 %, implying a risk of scrapie in China.

Keywords

Bovine Spongiform Encephalopathy Scrapie Sheep Breed Chronic Wasting Disease PRNP Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work was supported by the China National Transgenic Major Projects (No. 2009ZX08008-011B) and China National Department Public Benefit Research Foundation (No. 200903037).

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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Zouran Lan
    • 1
    • 2
  • Jinming Li
    • 1
  • Chengyou Sun
    • 1
  • Yutian Liu
    • 1
  • Yonggang Zhao
    • 1
  • Tianying Chi
    • 1
  • Xiaojing Yu
    • 1
  • Fangfang Song
    • 1
  • Zhiliang Wang
    • 1
    Email author
  1. 1.China Animal Health and Epidemiology CenterQingdaoPeople’s Republic of China
  2. 2.Shandong Center for Animal Disease Control and PreventionJinanPeople’s Republic of China

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