The genome sequence of a novel simian adenovirus in a chimpanzee reveals a close relationship to human adenoviruses
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Recently, several reports have revealed that some simian adenoviruses (AdVs) strains show a close relationship to human AdVs. In the present study, a simian AdV strain named SAdV-ch1 was detected in chimpanzees in China, and its complete genome was determined. Phylogenetic analysis revealed SAdV-ch1 clustering in a clade that was separate from all of the other simian AdVs but genetically close to a human AdV strain, HAdV-18 (GenBank no. GU191019), sharing 92.5 % sequence identity with it. Recombination analysis provided evidence that a recombination event had occurred between SAdV-ch1 and HAdV-61 (JF964962), where SAdV-ch1 exchanged partial of its hexon gene segment with HAdV-61, leading to the recombinant HAdV-31 (AM749299).
KeywordsSimian adenovirus Complete genome Phylogenetic analysis
This work was partly supported by China Postdoctoral Science Foundation No. 2013M531291 and 2013M530234, the National Natural Science Foundation of China No. 31302107, the Ph.D. Programs Foundation of the Ministry of Education of China No. 20113227120008, the Natural Science Foundation of Jiangsu Province no. BK2012289, the Special Fund for Preventive Medicine of Jiangsu Province no. Y2012067, and the Professional Research Foundation for Advanced Talents of Jiangsu University under grant no.12JDG085.
- 12.Wevers D, Metzger S, Babweteera F, Bieberbach M, Boesch C, Cameron K, Couacy-Hymann E, Cranfield M, Gray M, Harris LA, Head J, Jeffery K, Knauf S, Lankester F, Leendertz SA, Lonsdorf E, Mugisha L, Nitsche A, Reed P, Robbins M, Travis DA, Zommers Z, Leendertz FH, Ehlers B (2011) Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions. J Virol 85:10774–10784PubMedCentralPubMedCrossRefGoogle Scholar
- 13.Roy S, Vandenberghe LH, Kryazhimskiy S, Grant R, Calcedo R, Yuan X, Keough M, Sandhu A, Wang Q, Medina-Jaszek CA, Plotkin JB, Wilson JM (2009) Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates. PLoS Pathog 5:e1000503PubMedCentralPubMedCrossRefGoogle Scholar
- 15.Robinson CM, Zhou X, Rajaiya J, Yousuf MA, Singh G, DeSerres JJ, Walsh MP, Wong S, Seto D, Dyer DW, Chodosh J, Jones MS (2013) Predicting the next eye pathogen: analysis of a novel adenovirus. MBio 4(2):e00595-12Google Scholar
- 16.Walsh MP, Chintakuntlawar A, Robinson CM, Madisch I, Harrach B, Hudson NR, Schnurr D, Heim A, Chodosh J, Seto D, Jones MS (2009) Evidence of molecular evolution driven by recombination events influencing tropism in a novel human adenovirus that causes epidemic keratoconjunctivitis. PLoS One 4(6):e5635PubMedCentralPubMedCrossRefGoogle Scholar