Archives of Virology

, Volume 158, Issue 11, pp 2365–2370 | Cite as

Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010

  • Han-Gil Cho
  • Jang-Hoon Choi
  • Hyun-Kyung Lee
  • Su-Kyoung Mun
  • Jong-Bok Lee
  • Eek-Hoon Jho
  • Chun Kang
  • Young-Hee Lim
Brief Report


South Korean isolates of oseltamivir-resistant influenza viruses from 2005–2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008–2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.


Influenza viruses Neuraminidase Oseltamivir resistance 


Conflict of interest

The authors declare no conflicts of interest.

Supplementary material

705_2013_1734_MOESM1_ESM.doc (174 kb)
Supplementary material 1 (DOC 173 kb)


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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Han-Gil Cho
    • 2
    • 4
  • Jang-Hoon Choi
    • 3
  • Hyun-Kyung Lee
    • 2
  • Su-Kyoung Mun
    • 2
  • Jong-Bok Lee
    • 2
  • Eek-Hoon Jho
    • 4
  • Chun Kang
    • 3
  • Young-Hee Lim
    • 1
  1. 1.Department of Biomedical Science, College of Health ScienceKorea UniversitySeoulSouth Korea
  2. 2.Gyeonggi-do Institute of Health and EnvironmentSuwonSouth Korea
  3. 3.Center for Infectious DiseasesNational Institute of Health, Korea Centers for Disease Control and PreventionCheongwon-gunSouth Korea
  4. 4.University of SeoulSeoulSouth Korea

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