Archives of Virology

, Volume 159, Issue 3, pp 547–551

Ljungan virus is endemic in rodents in the UK

  • Anne-Marie Salisbury
  • Michael Begon
  • Winifred Dove
  • Bo Niklasson
  • James P. Stewart
Brief Report

Abstract

Ljungan virus is a recently identified member of the family Picornaviridae that was isolated from bank voles in Sweden. It has been shown to cause type 1 diabetes-like symptoms and myocarditis in bank voles (Myodes glareolus), and it has been suggested that it has zoonotic potential. Here, we show for the first time that Ljungan virus is prevalent (20–27 % positive by PCR) in four species of UK rodent (Myodes glareolus [bank vole], Apodemus sylvaticus [wood mouse], Microtus agrestis [field vole] and Mus musculus [house mouse]). Sequence analysis showed that Ljungan virus of genotypes 1 and 2 were present, although genotype 1 was more prevalent and more frequently associated with brain tissue. This study highlights the prevalence of Ljungan virus in the UK and the need for confirmation of its zoonotic potential.

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Anne-Marie Salisbury
    • 1
  • Michael Begon
    • 2
  • Winifred Dove
    • 3
  • Bo Niklasson
    • 4
  • James P. Stewart
    • 1
  1. 1.Department of Infection BiologyUniversity of Liverpool, Liverpool Science Park IC2LiverpoolUK
  2. 2.Ecology and Evolution of Infectious Disease GroupUniversity of LiverpoolLiverpoolUK
  3. 3.Department of Clinical Infection Microbiology and ImmunologyUniversity of LiverpoolLiverpoolUK
  4. 4.Apodemus ABStockholmSweden

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