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Archives of Virology

, Volume 158, Issue 10, pp 2059–2068 | Cite as

Proposal for a unified norovirus nomenclature and genotyping

  • Annelies Kroneman
  • Everardo Vega
  • Harry Vennema
  • Jan Vinjé
  • Peter A. White
  • Grant Hansman
  • Kim Green
  • Vito Martella
  • Kazuhiko Katayama
  • Marion Koopmans
Original Article

Abstract

Noroviruses belong to a genus of genetically diverse viruses within the family Caliciviridae and cause acute gastroenteritis in humans and animals. They are subdivided into genogroups, each of which further segregates into genotypes. Until recently, a new genotype was based on a defined pairwise distance cutoff of complete VP1 sequences, but with the increasing number of available norovirus sequences, this cutoff is no longer accurate, and sequences in the public database have been misclassified. In this paper, we demonstrate that the pairwise distance cutoff method can no longer be used and outline a phylogenetic approach to classify noroviruses. Furthermore, we propose a dual nomenclature using both ORF1 and VP1 sequences, as recombination is common and recognizing recombinant viruses may be relevant. With the continuing emergence of new norovirus lineages, we propose to coordinate nomenclature of new norovirus genotypes through an international norovirus working group.

Keywords

Typing Tool ORF2 Sequence Capsid Sequence Standard Deviation Criterion Orphan Cluster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We thank FBVE and Noronet network for collecting and sharing sequences, and Maarten Schippers (RIVM) for development of the R script.

Supplementary material

705_2013_1708_MOESM1_ESM.docx (139 kb)
Supplementary material 1 (DOCX 139 kb)
705_2013_1708_MOESM2_ESM.xls (1.7 mb)
Supplementary material 2 (XLS 1781 kb)

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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Annelies Kroneman
    • 1
  • Everardo Vega
    • 2
  • Harry Vennema
    • 1
  • Jan Vinjé
    • 2
  • Peter A. White
    • 3
  • Grant Hansman
    • 4
  • Kim Green
    • 5
    • 6
  • Vito Martella
    • 7
  • Kazuhiko Katayama
    • 8
  • Marion Koopmans
    • 1
    • 9
  1. 1.National Institute for Public Health and the EnvironmentBilthovenThe Netherlands
  2. 2.Centers for Disease Control and PreventionAtlantaUSA
  3. 3.School of Biotechnology and Biomolecular Sciences, Faculty of ScienceUniversity of New South WalesSydneyAustralia
  4. 4.CHS FoundationUniversity of HeidelbergHeidelbergGermany
  5. 5.Laboratory of Infectious Diseases, NIAID, NIHBethesdaUSA
  6. 6.Department of Cell Biology and Molecular GeneticsUniversity of MarylandCollege ParkUSA
  7. 7.Department of Veterinary Public HealthUniversity of Bari Aldo MoroValenzanoItaly
  8. 8.Department of Virology IINational Institute of Infectious DiseasesTokyoJapan
  9. 9.Virology DepartmentErasmus Medical CenterRotterdamThe Netherlands

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