Archives of Virology

, Volume 158, Issue 4, pp 839–844

The emergence of HIV-1 primary drug resistance genotypes among treatment-naïve men who have sex with men in high-prevalence areas in China

  • Juan Yang
  • Hui Xing
  • Jianli Niu
  • Lingjie Liao
  • Yuhua Ruan
  • Xiang He
  • Yi Feng
  • Zhe Li
  • Yiming Shao
Original Article

DOI: 10.1007/s00705-012-1557-7

Cite this article as:
Yang, J., Xing, H., Niu, J. et al. Arch Virol (2013) 158: 839. doi:10.1007/s00705-012-1557-7

Abstract

The prevalence of HIV-1 infection in men who have sex with men (MSM) in China has drastically increased, and circulating strains may have acquired transmitted drug resistance (TDR). We determined TDR genotypes among antiretroviral therapy (ART)-naïve MSM in 19 provinces/cities where HIV-1 prevalence among MSM is high, and found an overall 4.9 % TDR rate. Although protease inhibitors (PI) were not in the first-line antiretroviral drug list provided through the National ART Program, 70.4 % of the detected TDR belongs to this category. Our findings confirm the urgent need for TDR surveillance in order to optimize treatment effects of the National ART Program.

Supplementary material

705_2012_1557_MOESM1_ESM.tif (6.6 mb)
Supplementary Figure S1. Phylogenetic neighbor-joining tree for HIV-1polsequences. (A) CRF01_AE; (B) CRF07_BC; (C) subtype B. Horizontal branches are drawn in accordance with their relative genetic distances. Bootstrap values of 1,000 replicates are labeled on the major branches. The reference sequences for classifying HIV-1 genotypes were included and were originally obtained from the NIH/NIAID-funded HIV databases. (TIFF 6738 kb)
705_2012_1557_MOESM2_ESM.tif (3.3 mb)
Supplementary material 2 (TIFF 3378 kb)
705_2012_1557_MOESM3_ESM.tif (1.9 mb)
Supplementary material 3 (TIFF 1940 kb)

Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Juan Yang
    • 1
  • Hui Xing
    • 1
  • Jianli Niu
    • 1
  • Lingjie Liao
    • 1
  • Yuhua Ruan
    • 1
  • Xiang He
    • 1
  • Yi Feng
    • 1
  • Zhe Li
    • 1
  • Yiming Shao
    • 1
  1. 1.State Key Laboratory for Infectious Disease Prevention and ControlNational Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and PreventionBeijingChina

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