Archives of Virology

, Volume 158, Issue 4, pp 809–820

Unique characteristics of bat rabies viruses in big brown bats (Eptesicus fuscus)

  • April D. Davis
  • Paul A. Gordy
  • Richard A. Bowen
Original Article

Abstract

Rabies virus infection has been documented in several North American bat species, including Eptesicus fuscus. The virus-host relationship between bats and rabies virus (RV) is not well understood. The incidence of non-lethal RV exposure, based on the presence of viral neutralizing antibodies, demonstrates that exposure to RV does not always lead to clinical infection in bats. It is unknown how the route of exposure, rabies virus variant, or health of the bat affects the outcome following exposure. This paper describes the pathogenesis of two big brown bat RV variants in homologous host species. Our study demonstrates that RV variants obtained from the same species of bat from similar geographical areas may result in a diverse clinical progression of disease.

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Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • April D. Davis
    • 1
    • 2
  • Paul A. Gordy
    • 3
  • Richard A. Bowen
    • 3
  1. 1.Department of Microbiology, Immunology and PathologyColorado State UniversityFort CollinsUSA
  2. 2.Rabies Laboratory, New York State Department of HealthWadsworth CenterSlingerlandsUSA
  3. 3.Department of Biomedical SciencesColorado State UniversityFort CollinsUSA

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