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Archives of Virology

, Volume 158, Issue 3, pp 611–618 | Cite as

Molecular epidemiology of hepatitis C virus among different groups of people in the province of Fujian, China

  • Ying Ye
  • Yan-sheng Yan
  • Ge Chen
  • Ping-ping Yan
  • Wu-xiong Zheng
  • Yan-qin Deng
  • Xiu-hui Yang
  • Shou-li Wu
  • Zhi-shan Zhang
Original Article

Abstract

Genotyping of hepatitis C virus (HCV) can provide valuable information for prognosis and treatment duration prediction. To explore the genetic diversity of HCV in Fujian Province, China, 112, 104 and 48 anti-HCV-positive serum samples were collected from volunteer blood donors, IDUs and patients, respectively, from Jan 2008 to Dec 2008 and were genotyped through sequence analysis, followed by phylogenetic analysis in the C/E1 and NS5B regions. Genotypes could be determined for 85.61 and 84.85 % of samples in the C/E1 and NS5B region, respectively. 6a was the most prevalent subtype, which accounted for 42.04 and 43.75 % in the C/E1 and NS5B region, respectively. Mixed infection and potential recombination were detected in this study. Kappa tests indicated that similar results were obtained by two genotyping methods targeting the C/E1 and NS5B regions. The differences in the main prevalent subtype between the three target groups suggest diversity of HCV prevalence in different populations.

Keywords

Methadone Maintenance Treatment Predominant Genotype Predominant Subtype Volunteer Blood Donor NS5B Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This research was supported in part by blood centers of Fujian, Longyan and Quanzhou, methadone maintenance treatment clinics of Longyan, Fuqing, Quanzhou, Xiamen and Gutian, Fujian Provincial Hospital, the First Affiliated Hospital of Fujian Medical University, the First Hospital of Putian City, Fujian Provincial People’s Hospital and the Second People’s Hospital of Fujian Province. We thank all the subjects for their cooperation in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

705_2012_1513_MOESM1_ESM.doc (43 kb)
Supplementary material 1 (DOC 43 kb)

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Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Ying Ye
    • 1
    • 2
  • Yan-sheng Yan
    • 1
    • 2
  • Ge Chen
    • 2
  • Ping-ping Yan
    • 2
  • Wu-xiong Zheng
    • 2
  • Yan-qin Deng
    • 2
  • Xiu-hui Yang
    • 2
  • Shou-li Wu
    • 2
  • Zhi-shan Zhang
    • 3
  1. 1.Department of Pathogenic Biology, School of Basic MedicalFujian Medical UniversityFuzhouPeople’s Republic of China
  2. 2.Fujian Province Key Laboratory of Zoonosis ResearchFujian Center for Disease Control and PreventionFuzhouPeople’s Republic of China
  3. 3.Affiliated Quanzhou First Hospital of Fujian Medical UniversityQuanzhouPeople’s Republic of China

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