Molecular epidemiology of hepatitis C virus among different groups of people in the province of Fujian, China
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Genotyping of hepatitis C virus (HCV) can provide valuable information for prognosis and treatment duration prediction. To explore the genetic diversity of HCV in Fujian Province, China, 112, 104 and 48 anti-HCV-positive serum samples were collected from volunteer blood donors, IDUs and patients, respectively, from Jan 2008 to Dec 2008 and were genotyped through sequence analysis, followed by phylogenetic analysis in the C/E1 and NS5B regions. Genotypes could be determined for 85.61 and 84.85 % of samples in the C/E1 and NS5B region, respectively. 6a was the most prevalent subtype, which accounted for 42.04 and 43.75 % in the C/E1 and NS5B region, respectively. Mixed infection and potential recombination were detected in this study. Kappa tests indicated that similar results were obtained by two genotyping methods targeting the C/E1 and NS5B regions. The differences in the main prevalent subtype between the three target groups suggest diversity of HCV prevalence in different populations.
KeywordsMethadone Maintenance Treatment Predominant Genotype Predominant Subtype Volunteer Blood Donor NS5B Region
This research was supported in part by blood centers of Fujian, Longyan and Quanzhou, methadone maintenance treatment clinics of Longyan, Fuqing, Quanzhou, Xiamen and Gutian, Fujian Provincial Hospital, the First Affiliated Hospital of Fujian Medical University, the First Hospital of Putian City, Fujian Provincial People’s Hospital and the Second People’s Hospital of Fujian Province. We thank all the subjects for their cooperation in the study.
Conflict of interest
The authors declare that they have no conflict of interest.
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