Archives of Virology

, Volume 158, Issue 2, pp 417–424 | Cite as

Seasonal distribution and epidemiological characteristics of human metapneumovirus infections in pediatric inpatients in Southeast China

  • Yuqing Wang
  • Zhengrong Chen
  • Yong Dong Yan
  • Hongbo Guo
  • Chu Chu
  • Jing Liu
  • Yunfang Ding
  • Xuejun Shao
  • Jun Xu
  • Wei Ji
Original Article


Human metapneumovirus (hMPV) is an important respiratory pathogen in young children whose seasonal activity varies substantially from year to year among different populations. This study was conducted to investigate if there was a seasonal variation in the incidence of hMPV infection in young children and possible associations between hMPV infection and local meteorological parameters in Suzhou, China. A total of 6,655 children with acute respiratory tract infection (ARTI) admitted to the Children’s Hospital affiliated to Soochow University, Suzhou, were tested from January 2006 to December 2009 for the presence of hMPV using reverse-transcription polymerase chain reaction. The relationship between the presence of the virus and regional meteorological conditions was analyzed by linear and multivariate regression analysis. The overall hMPV infection incidence over the four-year study was 8.2 %, 8.1 %, 12.7 % and 7.4 % per year, respectively. Four hundred eighty-eight hMPV-positive children (78.2 %) were younger than 3 years of age. hMPV infections appear to have a seasonal distribution in Suzhou. In 2006, 2007 and 2009, the peak seasons were in December to January, while in 2008, the peak of hMPV activity occurred in May. The incidence of hMPV infection was negatively correlated with the average monthly temperature and rainfall. hMPV was one of the most common viral pathogens after respiratory syncytial virus that was associated with acute respiratory tract infection in children in Suzhou. hMPV infection occurred throughout the year with peaks during late winter and early spring. Climatic factors, especially monthly average temperature, may affect the prevalence of hMPV in Suzhou.


Respiratory Syncytial Virus Meteorological Factor Acute Respiratory Tract Infection Respiratory Virus Monthly Average Temperature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by Social Development, Science and Technology Projects of Suzhou (Grant No. SS0702).

Conflict of interest

The authors declare no conflict of interest associated with this article.


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Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Yuqing Wang
    • 1
  • Zhengrong Chen
    • 1
  • Yong Dong Yan
    • 1
  • Hongbo Guo
    • 1
  • Chu Chu
    • 1
  • Jing Liu
    • 1
  • Yunfang Ding
    • 2
  • Xuejun Shao
    • 2
  • Jun Xu
    • 2
  • Wei Ji
    • 1
  1. 1.The Department of Respiratory MedicineChildren’s Hospital Affiliated to Soochow UniversitySuzhouChina
  2. 2.The Department of Clinical LaboratoryChildren’s Hospital Affiliated to Soochow UniversitySuzhouChina

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