Advertisement

Archives of Virology

, Volume 157, Issue 12, pp 2411–2416 | Cite as

Epidemiological aspects of HCV infection in HIV-infected individuals in Piauí State, Northeast Brazil

  • Aldemir B. Oliveira-FilhoEmail author
  • Evaldo H. Oliveira
  • Jairo A. A. Castro
  • Letiano V. Silva
  • Antonio C. R. Vallinoto
  • José Alexandre R. Lemos
Brief Report

Abstract

In this study, the prevalence, genotypic frequency, and risk factors for HCV infection in 768 patients infected with HIV were determined. Fifty-two (6.77 %) HIV-positive individuals had anti-HCV antibodies and 26 (3.39 %) had HCV-RNA. Genotyping results indicated that all RT-PCR samples from patients infected with HCV belonged to genotype 1. Multivariate analysis revealed an association of HIV-HCV coinfection with drug use and having received blood transfusions before 1994. The relatively low prevalence of HCV infection in the HIV-positive population in that region may be a consequence of the small number of drug users in the sample, despite a strong association between HCV infection and drug use.

Keywords

HCV HIV Coinfection Epidemiology Brazil 

References

  1. 1.
    Alter MJ (2002) Prevention of spread of hepatitis C. Hepatology 36:93–98CrossRefGoogle Scholar
  2. 2.
    Alter MJ (2006) Epidemiology of viral hepatitis and HIV coinfection. J Hepatol 44:S6–S9PubMedCrossRefGoogle Scholar
  3. 3.
    Alter MJ, Seeff LB (2000) Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long-term outcome. Semin Liver Dis 20:17–35PubMedCrossRefGoogle Scholar
  4. 4.
    Anbazhagan GK, Krishnamoorthy S, Thiyagarajan T (2010) Seroprevalence of HCV and its co-infection with HBV and HIV among liver disease patients of South Tamil Nadu. World J Hepatol. doi: 10.4254/wjh.v2.i1.42 PubMedGoogle Scholar
  5. 5.
    van Asten L, Prins M (2004) Infection with concurrent multiple hepatic C virus genotype is associated with faster HIV disease progression. AIDS 18:2319–2324PubMedCrossRefGoogle Scholar
  6. 6.
    Campiotto S, Pinho JR, Carrilho FJ, Da Silva LC, Souto FJ, Spinelli V, Pereira LM, Coelho HS, Silva AO, Fonseca JC, Rosa H, Lacet CM, Bernardini AP (2005) Geographic distribution of hepatitis C virus genotypes in Brazil. Braz J Med Biol Res. doi: 10.1590/S0100-879X2005000100007 PubMedGoogle Scholar
  7. 7.
    CDC (2005) Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. MMWR Recomm Rep 52:1–16Google Scholar
  8. 8.
    Codes L, de Freitas LA, Santos-Jesus R, Vivitski L, Silva LK, Trepo C, Reis MG, Paraná R (2003) Comparative study of Hepatitis C virus genotypes 1 and 3 in Salvador, Bahia. Braz J Infect Dis 7:409–417PubMedCrossRefGoogle Scholar
  9. 9.
    Donahue JG, Munoz A, Ness PM, Brown DE Jr, Yawn DH, McAllister HA Jr, Reitz BA, Nelson KE (1992) The declining risk of post-transfusion hepatitis C virus infection. N Engl J Med 327:369–373PubMedCrossRefGoogle Scholar
  10. 10.
    Greub G, Ledergerber B, Battegay M, Grob P, Perrin L, Furrer H, Burgisser P, Erb P, Boggian K, Piffaretti JC, Hirschel B, Janin P, Francioli P, Flepp M, Telenti A (2000) Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study. Lancet 356:1800–1805PubMedCrossRefGoogle Scholar
  11. 11.
    Guindon S, Gascuel O (2003) A simple, fast and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52:696–704PubMedCrossRefGoogle Scholar
  12. 12.
    Hall TA (1999) Bioedit: a user-friendly biological sequence alignment editor and analysis program for windows 95/98/NT. Nucl Acids Symp Ser 41:95–98Google Scholar
  13. 13.
    Keane TM, Creevey CJ, Pentony MM, Naughton TJ, Mclnerney JO (2006) Assessment of methods for amino acid matrix and their use on empirical data shows that ad hoc assumptions for choice of matrix are not justified. BMC Evol Biol 6:29PubMedCrossRefGoogle Scholar
  14. 14.
    Klenerman P, Kim A (2007) HCV–HIV coinfection: simple messages from a complex disease. PLoS Med. doi: 10.1371/journal.pmed.0040240 PubMedGoogle Scholar
  15. 15.
    Lopes CL, Teles SA, Espírito-Santo MP, Lampe E, Rodrigues FP, Motta-Castro AR, Marinho TA, Reis NR, Silva AM, Martins RM (2009) Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil. Rev Saude Publica 43:S1–S7Google Scholar
  16. 16.
    Martins T, Narciso-Schiavon JL, de Schiavon L (2011) Epidemiology of hepatitis C virus infection. Rev Assoc Med Bras 57:107–112PubMedCrossRefGoogle Scholar
  17. 17.
    Mendes-Correa MC, Barone AA (2005) Hepatitis C in patients co-infected with human immunodeficiency virus: a review and experience of a Brazilian ambulatory. Rev Inst Med Trop S Paulo 47:59–64PubMedCrossRefGoogle Scholar
  18. 18.
    Mendes-Correa MC, Barone AA, Guastini C (2001) Hepatitis C virus seroprevalence and risk factors among patients with HIV infection. Rev Inst Med Trop Sao Paulo. doi: 10.1590/S0036-46652001000100003 PubMedGoogle Scholar
  19. 19.
    Mussi AD, Pereira RA, Corrêa e Silva Vde A, Martins RM, Souto FJ (2007) Epidemiological aspects of hepatitis C virus infection among HIV-infected individuals in Mato Grosso State. Central Brazil. Acta Trop. doi: 10.1016/j.actatropica.2007.08.001 Google Scholar
  20. 20.
    Oliveira ML, Yoshida CF, Telles PR, Hacker MA, Oliveira SA, Miguel JC, do O KM, Bastos FI (2009) Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies. Epidemiol Infect 137:970–979PubMedCrossRefGoogle Scholar
  21. 21.
    Oliveira-Filho AB, Pimenta AS, Rojas MF, Chagas MC, Crescente JA, Crespo DM, Lemos JA (2010) Prevalence and genotyping of hepatitis C virus in blood donors in the state of Pará, Northern Brazil. Mem Inst Oswaldo Cruz 105:103–106PubMedCrossRefGoogle Scholar
  22. 22.
    Oliveira-Filho AB, Pimenta AS, Rojas MF, Chagas MC, Crescente JA, Crespo DM, Lemos JA (2010) Likely transmission of hepatitis C virus through sharing of cutting and perforating instruments in blood donors in the State of Pará, Northern Brazil. Cad Saude Publica 26:837–844PubMedCrossRefGoogle Scholar
  23. 23.
    Pavan MHP, Aoki FH, Monteiro DTM, Gonçales NSL, Escanhoela CAA, Junior FLG (2003) Viral hepatitis in patients infected with human immunodeficiency virus. Braz J Infect Dis. doi: 10.1590/S1413-86702003000400005 PubMedGoogle Scholar
  24. 24.
    Rambaut A (2011) FigTree version 1.1.3. http://tree.bio.ed.ac.uk/software/figtree. Accessed 12 June 2011
  25. 25.
    Sanchez-Bueno F, Ortiz ML, Bermejo J, Miras M, Pons JA, Ramirez P, Robles R, Parrilla P (2006) Prognostic factors for hepatitis C recurrence in patients undergoing orthotopic liver transplantation. Transpl Immunol 17:47–50PubMedCrossRefGoogle Scholar
  26. 26.
    Segurado AC, Braga P, Etzel A, Cardoso MR (2004) Hepatitis C virus coinfection a cohort of HIV-infected individuals from Santos, Brazil: seroprevalence and associated factors. AIDS Patient Care STDS. doi: 10.1089/108729104322994829 PubMedGoogle Scholar
  27. 27.
    Silva MB, Andrade TM, Silva LK, Rodart IF, Lopes GB, Carmo TM, Zarife MA, Dourado I, Reis MG (2010) Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil. Mem Inst Oswaldo Cruz 105:299–303PubMedCrossRefGoogle Scholar
  28. 28.
    Staples CT Jr, Rimland D, Dudas D (2000) Hepatitis C in the HIV (human immunodeficiency virus) Atlanta V.A. (Veterans Affairs Medical Center) Cohort Study (HAVACS): the effect of coinfection on survival. Clin Infect Dis 30:409–410CrossRefGoogle Scholar
  29. 29.
    Thomas DL (2008) The Challenge of Hepatitis C in the HIV-Infected Person. Annu Rev Med. doi: 10.1146/annurev.med.59.081906.081110 PubMedGoogle Scholar
  30. 30.
    Treitinger A, Spada C, Silva EL, Miranda AFB, Oliveira OV, Silveira MVS, Verdi JC, Abdalla DSP (1999) Prevalence of serologic markers of HBV and HCV infection in HIV-1 seropositive patients in Florianópolis, Brazil. Braz J Infect Dis 3:1–5PubMedGoogle Scholar
  31. 31.
    Veras KN, Jacobina KS, Soares VY, Avelino MA, Vasconcelos Cde M, Parente JM (2009) Chronic hepatitis C virus in the state of Piauí, northeastern Brazil. Braz J Infect Dis 13:125–129PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Aldemir B. Oliveira-Filho
    • 1
    • 2
    Email author
  • Evaldo H. Oliveira
    • 3
  • Jairo A. A. Castro
    • 2
  • Letiano V. Silva
    • 4
  • Antonio C. R. Vallinoto
    • 5
  • José Alexandre R. Lemos
    • 2
    • 5
  1. 1.Faculdade de Ciências NaturaisCampus do Marajó-Breves, Universidade Federal do ParáBrevesBrasil
  2. 2.Laboratório de Biologia MolecularCentro de Hematologia e Hemoterapia do ParáBelémBrasil
  3. 3.Centro de Ciências da Saúde, Universidade Federal do PiauíTeresinaBrasil
  4. 4.Laboratório Central de Saúde Pública do PiauíTeresinaBrasil
  5. 5.Laboratório de VirologiaInstituto de Ciências Biológicas, Universidade Federal do ParáBelémBrasil

Personalised recommendations