Archives of Virology

, Volume 157, Issue 11, pp 2253–2255 | Cite as

Tick-borne encephalitis virus in Eastern Siberia: complete genome characteristics

  • Nina V. Kulakova
  • Evgenii I. Andaev
  • Sergei I. Belikov
Annotated Sequence Record


Tick-borne encephalitis (TBE) is one of the most important arboviral diseases across Eurasia. TBE virus (TBEV) is transmitted by tick bite and causes a potentially fatal neurological infection in humans. In the Russian Federation, TBE is endemic in most regions, with 3000-5000 cases of the disease annually. To characterise TBEV in Eastern Siberia, the complete genomes of five TBEV isolates from patients with different clinical manifestations were sequenced. The results show that the Siberian and Far Eastern subtypes of TBEV cause the disease in people in Eastern Siberia. Complete genome analysis revealed an unexpectedly high genetic variability within the Siberian subtype.


Siberian Group Translate Amino Acid Sequence DTCS Quick Start TBEV Strain Distinct Phylogenetic Lineage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was funded by International Science and Technology Center project No. 4006.

Supplementary material

705_2012_1412_MOESM1_ESM.pdf (188 kb)
Supplementary material 1 (PDF 188 kb)
705_2012_1412_MOESM2_ESM.pdf (169 kb)
Supplementary material 2 (PDF 168 kb)
705_2012_1412_MOESM3_ESM.pdf (327 kb)
Supplementary material 3 (PDF 327 kb)


  1. 1.
    Ecological situation in Zabaikalskii krai in 2010 (State report in Russian) Accessed 18 April 2012Google Scholar
  2. 2.
    Gritsun TS, Venugopal K, Zanotto PM, Mikhailov MV, Sall AA, Holmes EC, Polkinghorne I, Frolova TV, Pogodina VV, Lashkevich VA, Gould EA (1997) Complete sequence of two tick-borne flaviviruses isolated from Siberia and the UK: analysis and significance of the 5′ and 3′-UTRs. Virus Res 49(1):27–39PubMedCrossRefGoogle Scholar
  3. 3.
    Gritsun TS, Frolova TV, Zhankov AI, Armesto M, Turner SL, Frolova MP, Pogodina VV, Lashkevich VA, Gould EA (2003) Characterization of a siberian virus isolated from a patient with progressive chronic tick-borne encephalitis. J Virol 77(1):25–36PubMedCrossRefGoogle Scholar
  4. 4.
    Gritsun TS, Frolova TV, Pogodina VV, Lashkevich VA, Venugopal K, Gould EA (1993) Nucleotide and deduced amino acid sequence of the envelope gene of the Vasilchenko strain of TBE virus; comparison with other flaviviruses. Virus Res 27(2):201–209PubMedCrossRefGoogle Scholar
  5. 5.
    Kraminskaya N, Zhivolyapina RR, Meyerova RA, Perevoznikov VA (1965) Unusual strain of Tick-borne encephalitis virus, isolated from a patient with progressive chronic disease. Conf. on Actual problems of viral infections. Moscow, pp 190–191 (Article in Russian)Google Scholar
  6. 6.
    Andaev E et al (2007) Tick-borne encephalitis in Chita region and the etiology of the focal form with a fatal outcome. Bulletin of SB of RAMS, 4(126):60–65 (Article in Russian)Google Scholar
  7. 7.
    Hayasaka D, Ivanov L, Leonova GN, Goto A, Yoshii K, Mizutani T, Kariwa H, Takashima I (2001) Distribution and characterization of tick-borne encephalitis viruses from Siberia and far-eastern Asia. J Gen Virol 82(Pt 6):1319–1328PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Nina V. Kulakova
    • 1
  • Evgenii I. Andaev
    • 2
  • Sergei I. Belikov
    • 1
  1. 1.Laboratory of Analytical and Bioorganic ChemistryLimnological Institute of SB RASIrkutskRussia
  2. 2.Laboratory of Natural Focal Viruses InfectionIrkutsk Antiplague Research Institute of Siberia and Far EastIrkutskRussia

Personalised recommendations