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Archives of Virology

, Volume 157, Issue 10, pp 1959–1965 | Cite as

Molecular epidemiology of hepatitis C virus among injection drug users in Iran: a slight change in prevalence of HCV genotypes over time

  • Katayoun Samimi-Rad
  • Mohsen Nasiri Toosi
  • Ali Masoudi-nejad
  • Ali Najafi
  • Ramin Rahimnia
  • Fatemeh Asgari
  • Alireza Namazi Shabestari
  • Gholamreza Hassanpour
  • Seyed-Moayed Alavian
  • Freshteh Asgari
Brief Report

Abstract

Injecting drug users (IDUs) are the main at-risk population for hepatitis C virus (HCV) transmission. We studied HCV infection, risk factors, and genotype distribution in relation to the year of first injection among Iranian IDUs. Of a total of 126 specimens positive for HCV antibody, 93 (74 %) had detectible HCV RNA, and the NS5B gene was sequenced for 83, with genotype 3a (n = 48, 58 %) being predominant, followed by 1a (n = 35, 42 %). Tattooing was an independent predictor for HCV infection. No significant difference was found between HCV genotypes and IDU characteristics. Although there was no change in the distribution of prevalent genotypes before and after 1997, a slight variation in the prevalence was observed (p = 0.71). The difference in the prevalence of subtypes 1a and 3a (9.1 % in the period 1984-1996 and 18.2 % in the period 1997-2009) during 25 years was 9.1 %. These findings indicate a high prevalence of HCV infection among Iranian IDUs and highlights HCV-3a as the most prevalent subtype for the past 25 years. Harm-reduction strategies appear to be the most important measures to reduce the transmission of HCV in Iran.

Keywords

Thalassemia Syringe Sharing Iranian IDUs Average Evolutionary Distance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We would like to thank Dr. Ali Malakzadeh and his colleagues at West Health Center for their cooperation in sample collection. We thank Dr. Mehrdad Pedram (Dept. of Biotechnology and Medical Genetics, Zanjan University of Medical Sciences) for his careful editing of the manuscript and helpful comments.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Katayoun Samimi-Rad
    • 1
  • Mohsen Nasiri Toosi
    • 2
  • Ali Masoudi-nejad
    • 3
  • Ali Najafi
    • 3
  • Ramin Rahimnia
    • 4
  • Fatemeh Asgari
    • 1
  • Alireza Namazi Shabestari
    • 5
  • Gholamreza Hassanpour
    • 6
  • Seyed-Moayed Alavian
    • 7
  • Freshteh Asgari
    • 8
  1. 1.Department of Virology, School of Public HealthTehran University of Medical SciencesTehranIran
  2. 2.Department of Internal Medicine, Gastroenterology and Hepatology SectionTehran University of Medical SciencesTehranIran
  3. 3.Institute of Biochemistry and Biophysics and COE in BiomathematicsUniversity of TehranTehranIran
  4. 4.Department of Nano Medicine, School of Advanced Technologies in MedicineTehran University of Medical SciencesTehranIran
  5. 5.Department of Human Resource Management and Organizational DevelopmentTehran University of Medical SciencesTehranIran
  6. 6.Department of Mycology and Parasitology, School of Public HealthTehran University of Medical SciencesTehranIran
  7. 7.Research Center for Gastroenterology and Liver DiseaseBaqiatallah University of Medical SciencesTehranIran
  8. 8.Center for Disease Control, Deputy of HealthMinistry of Health and Medical EducationTehranIran

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