Archives of Virology

, Volume 157, Issue 8, pp 1579–1586 | Cite as

Correlation of viral load with bone marrow and hematological changes in pale patients with chronic hepatitis C virus

  • Abdel Raouf Abou El Azm
  • Hassan El-Bate
  • Lobna Abo-Ali
  • Nagwa Mansour
  • Hussin Ghoraba
  • Mohamed Labib Salem
Brief Report


Liver is considered the target of hepatitis C virus (HCV), which has marked tropism for hepatocytes. In this study, we investigated changes in bone marrow (BM) and blood and their correlation with viremia level in 30 pale patients with chronic HCV who were selected before antiviral therapy. Patients with BM positive for HCV RNA (53.33 %) showed moderate to high viremia, while patients with BM negative for RNA (46.67 %) had low viremia. There was no significant difference in the liver histopathology between patients with HCV-RNA-negative and positive BM. Patients with BM positive for HCV RNA showed significant changes in BM cells, including the degree of immune complex deposition and alterations in peripheral blood counts compared to patients with BM negative for RNA and healthy controls, suggesting that BM changes could be a sequel or a reservoir for HCV viremia.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Abdel Raouf Abou El Azm
    • 1
  • Hassan El-Bate
    • 1
  • Lobna Abo-Ali
    • 1
  • Nagwa Mansour
    • 2
  • Hussin Ghoraba
    • 3
  • Mohamed Labib Salem
    • 4
  1. 1.Department of Tropical Medicine and Infectious DiseasesTanta UniversityTantaEgypt
  2. 2.Department of Clinical PathologyTanta UniversityTantaEgypt
  3. 3.Department of PathologyTanta UniversityTantaEgypt
  4. 4.Department of Zoology, Faculty of Science, Immunology and Biotechnology UnitTanta UniversityTantaEgypt

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