Archives of Virology

, Volume 157, Issue 6, pp 1131–1136

Characterization of a highly pathogenic H5N1 avian influenza virus isolated from ducks in Eastern China in 2011

  • Wu Hai-bo
  • Guo Chao-tan
  • Lu Ru-feng
  • Xu Li-hua
  • Wo En-kang
  • You Jin-biao
  • Wang Yi-ting
  • Wang Qiao-gang
  • Wu Nan-ping
Brief Report

Abstract

This study describes the characterization of seven H5N1 avian influenza viruses from domestic ducks in Eastern China in 2011. Phylogenetic analysis showed these viruses were closely related to an H5N1 virus circulating in wild birds in Hong Kong. Some characteristics of these viruses were similar to those of an H5N1 strain that circulated in China and Vietnam (2003-2004). The virulence of three isolates was examined in chickens and mice, and they were found to be highly pathogenic in chickens but showed low pathogenicity in mice. These results suggest that continued H5N1 surveillance in poultry should be used as an early warning system for avian influenza outbreaks.

Supplementary material

705_2012_1259_MOESM1_ESM.doc (111 kb)
Supplementary material 1 (DOC 110 kb)
705_2012_1259_MOESM2_ESM.doc (26 kb)
Supplementary material 2 (DOC 24 kb)

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Wu Hai-bo
    • 1
    • 2
  • Guo Chao-tan
    • 2
  • Lu Ru-feng
    • 3
  • Xu Li-hua
    • 4
  • Wo En-kang
    • 2
  • You Jin-biao
    • 2
  • Wang Yi-ting
    • 2
  • Wang Qiao-gang
    • 2
  • Wu Nan-ping
    • 1
  1. 1.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  2. 2.Institute of BioengineeringZhejiang Academy of Medical SciencesHangzhouChina
  3. 3.Department of EmergencyThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhouChina
  4. 4.Animal Husbandry and Veterinary InstituteZhejiang Academy of Agricultural ScienceHangzhouChina

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