Molecular epidemiology of foot-and-mouth disease virus serotypes A and O with emphasis on Korean isolates: temporal and spatial dynamics
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We determined complete 1D gene sequences for one serotype A and seven additional serotype O Korean foot-and-mouth disease viruses (FMDV) and then analyzed them together with published sequences for 180 type A and 300 type O isolates from throughout the world using a Bayesian coalescent approach. Here, Korean serotype A virus was linked with those from Laos. Korean serotype O viruses were divided into three clades and were closely related to isolates from Japan, Thailand, the UK, France, Ireland, South Africa, and Singapore, as well as Laos. There was no apparent correlation between time, country, or host species and the evolution of global FMDVs. Additionally, our results showed that purifying selection acts on the overall 1D sequences and there was no evidence of recombination among the FMDV sequences. The evolutionary rates were 5.77 × 10−3 substitutions/site/year for serotype A and 4.81 × 10−3 substitutions/site/year for serotype O. Serotype A viruses diverged approximately 110 years ago, while serotype O isolates segregated approximately 127 years before the present. In both serotype isolates, the effective number of infections remained constant until the late 1990 s, after which the virus population size underwent a rapid, sharp decline until the present.
KeywordsBayesian Skyline Plot Korean Isolate Amino Acid Sequence Level High Probability Density Maximum Clade Credibility Tree
This study was supported by a grant from the Rural Development Administration of Korea.
- 3.Melo EC, López A (2002) Control of foot and mouth disease: the experience of the Americas. Rev Sci Tech Off Int Epiz 21:695–698Google Scholar
- 7.Mohapatra JK, Priyadarshini P, Pandey L, Subramaniam S, Sanyal A, Hemadri D, Pattnaik B (2009) Analysis of the leader proteinase (L(pro)) region of type A foot-and-mouth disease virus with due emphasis on phylogeny and evolution of the emerging VP3(59)-deletion lineage from India. Virus Res 141:34–46PubMedCrossRefGoogle Scholar
- 8.Schumann KR, Knowles NJ, Davies PR, Midgley RJ, Valarcher JF, Raoufi AQ, McKenna TS, Hurtle W, Burans JP, Martin BM, Rodriguez LL, Beckham TR (2008) Genetic characterization and molecular epidemiology of foot-and-mouth disease viruses isolated from Afghanistan in 2003–2005. Virus Genes 36:401–413PubMedCrossRefGoogle Scholar
- 16.Ko YJ, Lee HS, Jeoung HY, Heo EJ, Ko HR, Chang BS, Joo HD, Gerelmaa U, Dashzeveg B, Tserendorj S, Sodnomdarjaa R, Park JH, Kweon CH, Cho IS, Paik SG (2010) Use of a baculovirus-expressed structural protein for the detection of antibodies to foot-and-mouth disease virus type A by a blocking enzyme-linked immunosorbent assay. Clin Vaccine Immunol 17:194–198PubMedCrossRefGoogle Scholar
- 17.Hall TA (1999) BIOEDIT: a user-friendly biological sequence alignment editor and analysis program for windows 95/98/NT. Nucleic Acid Symp Ser 41:95–98Google Scholar
- 21.Nielsen R, Yang Z (1998) Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene. Genetics 48:929–936Google Scholar
- 33.Rambaut A (2006) Available at http://evolve.zoo.ox.ac.uk/beast
- 37.Tully DC, Fares MA (2006) Unravelling selection shifts among foot-and-mouth disease virus (FMDV) serotypes. Evol Bioinform 2:237–251Google Scholar