Archives of Virology

, Volume 155, Issue 11, pp 1803–1811 | Cite as

Molecular detection of porcine kobuviruses in pigs in Korea and their association with diarrhea

  • Seong-Jun Park
  • Hye-Kwon Kim
  • Hyoung-Joon Moon
  • Dae-Sub Song
  • Se-Mi Rho
  • Jae-Yeon Han
  • Van-Giap Nguyen
  • Bong-Kyun ParkEmail author
Original Article


Kobuviruses are small, non-enveloped viruses with a single-stranded, positive-sense genomic RNA, belonging to the family Picornaviridae, a highly diverse family of important pathogens of human and other animals. Porcine kobuvirus has been found recently, and consequently, information about the virus is lacking. In this study, we identified porcine kobuviruses from pigs in Korea by RT-PCR, cloning and sequencing, and we showed the existence of genetic diversity among geographically separated porcine kobuviruses through genetic and phylogenetic analysis. Epidemiological studies of porcine kobuvirus linked to diarrhea indicated that porcine kobuvirus infections are endemic in diarrheic pigs in Korea. Statistical analysis of the porcine kobuvirus positive rate between diarrheic and healthy pigs as well as a survey for other enteric pathogens in diarrheic pigs suggests that porcine kobuvirus may play a role as a causative agent of gastroenteritis in pigs.


Porcine Epidemic Diarrhea Virus Enteric Pathogen Aichi Virus Porcine Kobuvirus Bacterial Enteric Pathogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by a grant (Code #20070401034009) from BioGreen 21 Program, Rural Development Administration, Republic of Korea.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Seong-Jun Park
    • 1
  • Hye-Kwon Kim
    • 1
  • Hyoung-Joon Moon
    • 2
  • Dae-Sub Song
    • 2
  • Se-Mi Rho
    • 1
  • Jae-Yeon Han
    • 1
  • Van-Giap Nguyen
    • 1
  • Bong-Kyun Park
    • 1
    Email author
  1. 1.Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and BK21 Program for Veterinary ScienceSeoul National UniversitySeoulKorea
  2. 2.Research Unit, Green Cross Veterinary ProductsYong-InKorea

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