Evolution of dengue virus in Mexico is characterized by frequent lineage replacement
- 369 Downloads
Both dengue fever and its more serious clinical manifestation, dengue hemorrhagic fever, represent major public health concerns in the Americas. To understand the patterns and dynamics of virus transmission in Mexico, a country characterized by a marked increase in dengue incidence in recent years, we undertook a molecular evolutionary analysis of the largest sample of Mexican strains of dengue virus compiled to date. Our E gene data set comprises sequences sampled over a period of 27 years and representing all of the Mexican states that are endemic for dengue. Our phylogenetic analysis reveals that, for each of the four dengue viruses (DENV-1 to DENV-4), there have been multiple introductions of viral lineages in Mexico, with viruses similar to those observed throughout the Americas, but there has been strikingly little co-circulation. Rather, dengue virus evolution in Mexico is typified by frequent lineage replacement, such that only a single viral lineage dominates in a specific serotype at a specific time point. Most lineage replacement events involve members of the same viral genotype, although a replacement event involving different genotypes was observed with DENV-2, and viral lineages that are new to Mexico are described for DENV-1, DENV-3 and DENV-4.
KeywordsMarkov Chain Monte Carlo Dengue Virus Dengue Hemorrhagic Fever Mexican Population Viral Lineage
The authors wish to thank Ms. Silvia Tenorio-Salgado for technical assistance. This work was supported by a grant FOSSIS-CONACYT SALUD-2005-01-13852 to JRC.
- 13.Guindon S, Gascuel O (2003) A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Mol Biol Evol 52:696–704Google Scholar
- 15.Holmes EC (2009) The evolution and emergence of RNA viruses. In: Harvey PH, May RM (eds) Oxford series in ecology and evolution (OSEE). Oxford University Press, OxfordGoogle Scholar
- 22.Loroño-Pino MA, Farfán-Ale JA, Zapata-Peraza AL, Rosado-Paredes EP, Flores-Flores LF, García-Rejón JE, Díaz FJ, Blitvich BJ, Andrade-Narváez M, Jiménez-Ríos E, Blair CD, Olson KE, Black WC, Beaty BJ 4th (2004) Introduction of the American/Asian genotype of dengue 2 virus into the Yucatan State of Mexico. Am J Trop Med Hyg 71:485–492PubMedGoogle Scholar
- 23.Lozano-Fuentes S, Fernandez-Salas I, de Lourdes Muñoz M, Garcia-Rejon J, Olson KE, Beaty BJ, Black WC 4th (2009) The Neovolcanic axis is a barrier to gene flow among Aedes aegypti populations in Mexico that differ in vector competence for dengue 2 virus. PLoS Negl Trop Dis 3:e468PubMedCrossRefGoogle Scholar
- 26.Ramos MM, Mohammed H, Zielinski-Gutierrez E, Hayden MH, Lopez JL, Fournier M, Trujillo AR, Burton R, Brunkard JM, Anaya-Lopez L, Banicki AA, Morales PK, Smith B, Muñoz JL, Waterman SH, Dengue Serosurvey Working Group (2008) Epidemic dengue and dengue hemorrhagic fever at the Texas-Mexico border: results of a household-based seroepidemiologic survey, December 2005. Am J Trop Med Hyg 78:364–369PubMedGoogle Scholar
- 32.Sittisombut N, Sistayanarain A, Cardosa MJ, Salminen M, Damrongdachakul S, Kalayanarooj S, Rojanasuphot S, Supawadee J, Maneekarn N (1997) Possible occurrence of a genetic bottleneck in dengue serotype 2 viruses between the 1980 and 1987 epidemic seasons in Bangkok, Thailand. Am J Trop Hyg Med 57:100–108Google Scholar