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Archives of Virology

, Volume 155, Issue 9, pp 1401–1412 | Cite as

Evolution of dengue virus in Mexico is characterized by frequent lineage replacement

  • Erik Carrillo-Valenzo
  • Rogelio Danis-Lozano
  • Jorge X. Velasco-Hernández
  • Gilma Sánchez-Burgos
  • Celia Alpuche
  • Irma López
  • Claudia Rosales
  • Cécile Baronti
  • Xavier de Lamballerie
  • Edward C. Holmes
  • José Ramos-Castañeda
Original Article

Abstract

Both dengue fever and its more serious clinical manifestation, dengue hemorrhagic fever, represent major public health concerns in the Americas. To understand the patterns and dynamics of virus transmission in Mexico, a country characterized by a marked increase in dengue incidence in recent years, we undertook a molecular evolutionary analysis of the largest sample of Mexican strains of dengue virus compiled to date. Our E gene data set comprises sequences sampled over a period of 27 years and representing all of the Mexican states that are endemic for dengue. Our phylogenetic analysis reveals that, for each of the four dengue viruses (DENV-1 to DENV-4), there have been multiple introductions of viral lineages in Mexico, with viruses similar to those observed throughout the Americas, but there has been strikingly little co-circulation. Rather, dengue virus evolution in Mexico is typified by frequent lineage replacement, such that only a single viral lineage dominates in a specific serotype at a specific time point. Most lineage replacement events involve members of the same viral genotype, although a replacement event involving different genotypes was observed with DENV-2, and viral lineages that are new to Mexico are described for DENV-1, DENV-3 and DENV-4.

Keywords

Markov Chain Monte Carlo Dengue Virus Dengue Hemorrhagic Fever Mexican Population Viral Lineage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors wish to thank Ms. Silvia Tenorio-Salgado for technical assistance. This work was supported by a grant FOSSIS-CONACYT SALUD-2005-01-13852 to JRC.

Supplementary material

705_2010_721_MOESM1_ESM.doc (28 kb)
Supplementary Table 1 (DOC 28 kb)

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Erik Carrillo-Valenzo
    • 1
    • 2
  • Rogelio Danis-Lozano
    • 3
  • Jorge X. Velasco-Hernández
    • 4
  • Gilma Sánchez-Burgos
    • 5
  • Celia Alpuche
    • 6
  • Irma López
    • 6
  • Claudia Rosales
    • 6
  • Cécile Baronti
    • 7
  • Xavier de Lamballerie
    • 7
  • Edward C. Holmes
    • 8
  • José Ramos-Castañeda
    • 1
  1. 1.Centro de Investigaciones Sobre Enfermedades InfecciosasInstituto Nacional de Salud PúblicaCuernavacaMéxico
  2. 2.Departamento de EpidemiologíaServicios de Salud de MorelosCuernavacaMéxico
  3. 3.Centro Regional de Investigaciones en Salud PúblicaInstituto Nacional de Salud PúblicaTapachulaMéxico
  4. 4.Programa en Matemáticas Aplicadas y ComputaciónInstituto Mexicano del PetroleoMéxico D.F.México
  5. 5.Unidad de Investigación Médica, CMN Ignacio García TéllezInstituto Mexicano del Seguro SocialMéridaMéxico
  6. 6.Instituto de Diagnóstico y Referencia EpidemiológicosSecretaria de SaludMéxico D.F.México
  7. 7.Unité des Virus EmergentsUniversité de la MéditerranéeMarseilleFrance
  8. 8.Center for Infectious Disease Dynamics, Department of BiologyThe Pennsylvania State UniversityUniversity ParkUSA

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