Archives of Virology

, Volume 155, Issue 3, pp 411–416 | Cite as

The distribution of feline immunodeficiency virus in tissue compartments of feral domestic cats

  • Jessica J. HaywardEmail author
  • Allen G. Rodrigo
Brief Report

Prevalence and subtype studies of feline immunodeficiency virus (FIV) in the domestic cat (Felis catus) have been conducted thoroughly. However, the intrahost dynamics of FIV have been less well studied. Here, we determine the diversity of FIV env V3–V6 sequences isolated from multiple tissues of naturally infected feral cats. Using nested PCR, FIV was amplified from non-lymphoid tissues from eight of sixteen cats that had amplifiable proviral FIV DNA in the popliteal lymph node. In general, we found low intrahost FIV diversity, but there was evidence of tissue compartmentalization in one cat.

Feline immunodeficiency virus is a lentivirus, closely related to human immunodeficiency virus (HIV), which can cause immunodeficiency in F. catus [17]. FIV has been detected in a number of tissue types, including lymphoid tissue, central nervous system (CNS), bone marrow, intestine, liver and lung [2, 4, 15, 22].

Compartmentalization is the restriction of virus movement between different tissues...


Feline Immunodeficiency Virus Proviral Load Feline Immunodeficiency Virus Infection High Proviral Load Random Leaf 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors wish to thank Dr. Emma Marks for editing. Sequencing was done at the Allan Wilson Centre, Massey University, Auckland. Feral cats were provided by the New Zealand Department of Conservation. This research was funded by the Allan Wilson Centre for Molecular Ecology and Evolution, and The University of Auckland. Jessica Hayward was supported by a University of Auckland Doctoral Scholarship.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Bioinformatics Institute, Allan Wilson Centre for Molecular Ecology and Evolution, School of Biological SciencesThe University of AucklandAucklandNew Zealand
  2. 2.Baker Institute for Animal Health, College of Veterinary MedicineCornell UniversityIthacaUSA

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