Archives of Virology

, Volume 155, Issue 1, pp 117–121 | Cite as

Tula hantavirus NSs protein accumulates in the perinuclear area in infected and transfected cells

  • Jussi Oskari Virtanen
  • Kirsi Maria Jääskeläinen
  • Janica Djupsjöbacka
  • Antti Vaheri
  • Alexander Plyusnin
Brief Report


The small RNA segment of some hantaviruses (family Bunyaviridae) encodes two proteins: the nucleocapsid protein and, in an overlapping reading frame, a non-structural (NSs) protein. The hantavirus NSs protein, like those of orthobunya- and phleboviruses, counteracts host innate immunity. Here, for the first time, the NSs protein of a hantavirus (Tula virus) has been observed in infected cells and shown to localize in the perinuclear area. Transiently expressed NSs protein showed similar localization, although the kinetics was slightly different, suggesting that to reach its proper location in the infected cell, the NSs protein does not have to cooperate with other viral proteins.


Hantavirus (BunyaviridaeTula virus Nonstructural (NSs) protein 


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jussi Oskari Virtanen
    • 1
  • Kirsi Maria Jääskeläinen
    • 1
  • Janica Djupsjöbacka
    • 1
  • Antti Vaheri
    • 1
  • Alexander Plyusnin
    • 1
  1. 1.Infection Biology Research Program, Department of Virology, Haartman InstituteUniversity of HelsinkiHelsinkiFinland

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