Archives of Virology

, Volume 154, Issue 12, pp 1923–1927 | Cite as

Detection of Human Bocavirus-2 in children with acute Gastroenteritis in South Korea

  • Tae-Hee Han
  • Cheol-Hwan Kim
  • Sang-Hun Park
  • En-Jung Kim
  • Ju-Young Chung
  • Eung-Soo Hwang
Brief Report

Abstract

Human bocavirus (HBoV)-2, a new parvovirus, has been identified in stool samples and is suggested to be one of the etiologic agents of acute gastroenteritis (GE). The purpose of this study was to investigate the prevalence of HBoV-2 in children with GE. Stool samples were collected from 358 children hospitalized with GE. HBoV-2 was detected in 3.6% of the patients. HBoV-2 was co-detected with other viral agents in 53.8% of the patients. These findings suggest that HBoV-2 may be an etiologic agent in GE, but further studies are needed due to frequent co-detection with other enteric viruses.

Notes

Acknowledgment

This study was partly supported by a research grant (2008) from Inje University.

References

  1. 1.
    Kapoor A, Slikas E, Simmonds P, Chieochansin T, Naeem A, Shaukat S, Alam MM, Sharif S, Angez M, Zaidi S, Delwart E (2009) A newly identified species in human stool. J Infect Dis 199:196–200CrossRefPubMedGoogle Scholar
  2. 2.
    Arthur JL, Higgins GD, Davidson GP, Ratcliff RM (2009) A novel bocavirus associated with acute gastroenteritis in Australian children. PLoS 5:e4Google Scholar
  3. 3.
    Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B (2005) Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci USA 101:12891–12896CrossRefGoogle Scholar
  4. 4.
    Kesebir D, Vazquez M, Weibel C, Shapiro ED, Ferguson D, Landry ML, Khan JS (2006) Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus. J Infect Dis 194:1276–1282CrossRefPubMedGoogle Scholar
  5. 5.
    Chung JY, Han TH, Kim SW, Kim CK, Hwang ES (2007) Detection of viruses identified recently in children with acute wheezing. J Med Virol 79:1238–1243CrossRefPubMedGoogle Scholar
  6. 6.
    Allander T, Jartti T, Gupta S, Niesters HG, Lehtein P, Osterback R, Vuorinen T, Waris M, Bjerkner A, Tiveljung-Lindell A, van den Hoogen BG, Hyypia t, Ruuskanen O (2007) Human bocavirus and acute wheezing in children. Clin Infect Dis 44:904–910CrossRefPubMedGoogle Scholar
  7. 7.
    Vallet C, Pons-Catalano C, Mandelcwaig A, Wang A, Raymond J, Lebon P, Gendrel D (2009) Human bocavirus: a cause of severe asthma exacerbation in children. J Pediatr 155:286–288CrossRefPubMedGoogle Scholar
  8. 8.
    Weissbrich BB, Neske F, Schubert J, Tollmann F, Blath K, Blessing K, Kreth HW (2006) Frequent detection of bocavirus DNA in German children with respiratory tract infections. BMC Infect Dis 6:109CrossRefPubMedGoogle Scholar
  9. 9.
    Arden KE, McErlean P, Nissen MD, Sloots TP, Mackay IM (2006) Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections. J Med Virol 78:1232–1240CrossRefPubMedGoogle Scholar
  10. 10.
    Vicente D, Cilla G, Montes M, Perez-Yarza-EG, Perez-Trallero E (2007) Human bocavirus, a respiratory and enteric virus. Emerg Infect Dis 13:636–637CrossRefPubMedGoogle Scholar
  11. 11.
    Albuquerque MC, Rocha LN, Benati FJ, Soares CC, Maranhao AG, Ramirez ML, Erdman D, Santos N (2007) Human bocavirus infection in children with gastroenteritis, Brazil. Emerg Infect Dis 13:1756–1758CrossRefPubMedGoogle Scholar
  12. 12.
    Lau SK, Yip CC, Que TL, Lee RA, Au-Yeng RK, Zhou B, So LY, Lau YL, Chan KH, Woo PC, Yuen KY (2007) Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong. J Infect Dis 196:986–993CrossRefPubMedGoogle Scholar
  13. 13.
    Cheng WX, Jin Y, Duan ZJ, Xu ZQ, Qi HM, Zhang Q, Yu JM, Zhu L, Jin M, Liu N, Cui SX, Li HY, Fang ZY (2007) Human bocavirus in children hospitalized for acute gastroenteritis: a case control study. Clin Infect Dis 47:161–167CrossRefGoogle Scholar
  14. 14.
    Chieochansin T, Thongmee C, Vimolket L, Theamboonlers A, Poovorawan Y (2008) Human bocavirus infection in children with acute gastroenteritis and healthy controls. Jpn J Infect Dis 61:479–481PubMedGoogle Scholar
  15. 15.
    Lee JI, Chung JY, Han TH, Song MO, Hwang ES (2007) Detection of human bocavirus in children hospitalized because of acute gastroenteritis. J Infect Dis 196:994–997CrossRefPubMedGoogle Scholar
  16. 16.
    Kojima S, Kageyama T, Fukushi S, Hoshino FB, Shinohara M, Uchida K, Natori K, Takeda N, Katayama K (2002) Genogroup-specific PCR primers for detection of Norwalk-like viruses. J Virol Methods 100:107–114CrossRefPubMedGoogle Scholar
  17. 17.
    Yan H, Yagyu F, Okitsu S, Nishio O, Ushijima H (2003) Detection of norovirus (GI, GII), sapovirus an dastrovirus in fecal samples using reverse transcription single round multiplex PCR. J Virol Methods 114:37–44CrossRefPubMedGoogle Scholar
  18. 18.
    Belliot G, Laveran H, Monroe SS (1997) Detection and genetic differentiation of human astroviruses: phylogenetic grouping varies by. coding region 142:1323–1334Google Scholar
  19. 19.
    Shan TL, Zhang W, Guo W, Cui L, Yuan CL, Dai XQ, Shen Q, Yang ZB, Zhu JG, Hua XG (2009) The first detection of human bocavirus 2 infections in China. J Clin Virol (Online publication ahead of print)Google Scholar
  20. 20.
    Campe H, Hartberger C, Snig A (2008) Role of Human bocavirus infection sin outbreaks of gastroenteritis. J Clin Virol 43:340–342CrossRefPubMedGoogle Scholar
  21. 21.
    Szomor KN, Kapusinszky B, Riqo Z, Kis Z, Rossa M, Farkas A, Szilaqyi A, Berencsi G, Takacs M (2009) Detection of human bocavirus from fecal samples of Hungarian children with acute gastroenteritis. 52:17–21Google Scholar
  22. 22.
    Huang Y, Mao P, Wang H (2009) Detection of, an frequent co-infection with, human bocavirus in fecal specimens from children in Wuhan, China. Clin Microbiol Infect (Online publication ahead of print)Google Scholar
  23. 23.
    Chung JY, Han TH, Kim JS, Kim SW, Park CG, Hwang ES (2008) Th1 and TH2 cytokine levels in nasopharyngeal aspirates from children with human bocavirus bronchiolitis. J Clin Virol 43:223–225CrossRefPubMedGoogle Scholar
  24. 24.
    Neske F, Blessing K, Tollmann F, Schubert J, Rethwilm A, Kreth HW, Weissbrich B (2007) Real-time PCR for diagnosis of human bocavirus infections and phylogenetic analysis. J Clin Microbiol 45:2116–2122CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Tae-Hee Han
    • 1
  • Cheol-Hwan Kim
    • 2
  • Sang-Hun Park
    • 3
  • En-Jung Kim
    • 3
  • Ju-Young Chung
    • 4
  • Eung-Soo Hwang
    • 5
  1. 1.Department of Laboratory Medicine, Sanggyepaik HospitalInje University College of MedicineSeoulKorea
  2. 2.Department of Family MedicineSungkyunkwan University School of MedicineSeoulKorea
  3. 3.Virus TeamSeoul Metropolitan Government Research Institute of Public Health and EnvironmentSeoulKorea
  4. 4.Department of Pediatrics, Sanggyepaik HospitalInje University College of MedicineSeoulKorea
  5. 5.Department of Microbiology and ImmunologySeoul National University College of MedicineSeoulKorea

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