Phylogenetic analysis of a near-full-length sequence of an erythrovirus genotype 3 strain isolated in Brazil
- 82 Downloads
Human parvovirus B19 is the only member of the genus Erythrovirus that causes human disease. Recent findings of several strains with considerable sequence divergence from B19 have suggested a new classification for parvovirus genotypes as 1 (B19), 2 (A-6 and LaLi) and 3 (V9). In their overall DNA sequence, the three genotypes differ by ~10%. Here, we report the isolation of a genotype-3-related strain named BR543 during a prospective study conducted in Sao Paulo, Brazil. Analysis of the nearly full-length genome sequence of BR543 indicates that this B19 variant sequence clusters with Gh2768, a strain from Ghana belonging to subtype 3b, and showed mostly synonymous substitutions.
KeywordsBR543 Strain Erythema Infectiosum Good Evolutionary Model Considerable Sequence Divergence Common Human Pathogen
- 6.Freitas RB, Melo FL, Oliveira DS, Romano CM, Freitas MRC, Macedo O, Linhares AC, Zanotto PMA, Durigon EL (2008) Molecular characterization of human erythrovirus B19 strains obtained from patients with several clinical presentations in the Amazon region of Brazil. J Clin Virol 43:60–65PubMedCrossRefGoogle Scholar
- 8.Pattison JR, Jones SE, Hodgson J, Davis LR, White JM, Stroud CE, Murtaza L (1981) Parvovirus infections and hypoplastic crisis sickle-cell anaemia. Lancet 1:604–665Google Scholar
- 14.Young NS (1996) Parvovirus. In: Fields BN, Knipe DM, Howley PM (eds) Fields virology. Lippincott-Raven, Philadelphia, p 2190Google Scholar