Archives of Virology

, Volume 154, Issue 7, pp 1139–1142 | Cite as

Seroprevalence and molecular epidemiology of enterovirus 71 in Germany

  • Sabine Diedrich
  • Anna Weinbrecht
  • Eckart Schreier
Brief Report


Enterovirus 71 (EV71) has emerged as a significant pathogen with potential to cause large outbreaks. Because little is known about its seroprevalence and molecular epidemiology in Germany, data for 1997–2007 are presented. Four hundred thirty-six sera from persons aging 10 months to 75 years were tested in a neutralisation test; 63.4% of pre-school children were seronegative, whereas about 75% of adults had antibodies to EV71. Phylogenetic analysis of 28 isolates associated with neurological or cutaneous manifestations showed that isolates belonging to genogroup C1 predominated in 2000–2005, followed by a change to genogroup C2 in 2006 and 2007. This shows the importance of monitoring the diversity of one of the most relevant neurotropic enteroviruses.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Sabine Diedrich
    • 1
  • Anna Weinbrecht
    • 1
  • Eckart Schreier
    • 1
  1. 1.Robert Koch InstituteBerlinGermany

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