Efficacy of phthalocyanine tetrasulfonate against mouse-adapted human prion strains
In vitro and in vivo studies have shown that phthalocyanine tetrasulfonate (PcTS), a cyclic tetrapyrrole compound, is an efficient antiscrapie drug. To investigate the spectrum of PcTS against prion diseases, we tested the effect of PcTS on two mouse-adapted human strains. We also tested PcTS in rodents infected with two scrapie strains (139A and 263K). PcTS treatment significantly prolonged mean survival times of all infected animals. These results show that PcTS is effective on different prion strains, confirming its potential use for prion therapy.
KeywordsScrapie 263K Strain Transmissible Spongiform Encephalopathy Pentosan Polysulfate Prion Strain
The skillful technical assistance of Nicola Bellizzi, Maurizio Bonanno, Ivano Itro, and Elfino Laconi is gratefully acknowledged. We thank Dr. Alessandra Garozzo and Mr. Marco Del Re for editorial assistance. This work was partially supported by the Istituto Superiore di Sanità, and by the “Progetto multidisciplinare sulla terapia delle malattie da virus”.