Archives of Virology

, 154:421 | Cite as

Serological survey of avian H5N2-subtype influenza virus infections in human populations

  • Yoshinao Yamazaki
  • Mikio Doy
  • Nobuhiko Okabe
  • Yoshinori Yasui
  • Kazutoshi Nakashima
  • Takashi Fujieda
  • Shin-ichi Yamato
  • Yuichi Kawata
  • Tsuyoshi Ogata
Original Article

Abstract

To investigate the distribution of antibodies against H5N2 influenza virus in humans living in Ibaraki prefecture, Japan, 266 single serum samples were collected to perform serological tests. Results were compared to investigate the relationship between positive results and several factors. The number of positive serum neutralization antibody titers (≥40) against avian influenza virus A/H5N2 was significantly greater (P < 0.05) among poultry workers, in comparison to a Japanese healthy population. The geometric mean titers of serum neutralization antibody against A/H5N2 were significantly higher (P < 0.05) among Ibaraki inhabitants and poultry workers (P < 0.0001) when compared to a Japanese healthy population. Seropositivity against A/H5N2 virus was significantly (P < 0.05) associated with age (≥50 years old) in poultry workers. These results suggest that seropositivity against H5N2 virus in Ibaraki specimens is significantly higher than those of a Japanese healthy population and that the surveillance of avian influenza viruses is very important to evaluate the invasion or emergence of new pandemic influenza viruses from species other than humans.

References

  1. 1.
    Bean WJ, Kawaoka Y, Wood JM, Pearson JE, Webster RG (1985) Characterization of virulent and avirulent A/chicken/Pennsylvania/83 influenza A viruses: potential role of defective interfering RNAs in nature. J Virol 54:151–160PubMedGoogle Scholar
  2. 2.
    Beare AS, Webster RG (1991) Replication of avian influenza viruses in humans. Arch Virol 119:37–42PubMedCrossRefGoogle Scholar
  3. 3.
    Buxton Bridges C, Katz JM, Seto WH, Chan PK, Tsang D, Ho W, Mak KH, Lim W, Tam JS, Clarke M, Williams SG, Mounts AW, Bresee JS, Conn LA, Rowe T, Hu-Primmer J, Abernathy RA, Lu X, Cox NJ, Fukuda K (2000) Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong. J Infect Dis 181:344–348PubMedCrossRefGoogle Scholar
  4. 4.
    Coleman MT, Dowdle WR, Pereira HG, Schild GC, Chang WK (1968) The Hong Kong-68 influenza A2 variant. Lancet 2:1384–1386PubMedCrossRefGoogle Scholar
  5. 5.
    Donatelli I, Campitelli L, Di Trani L, Puzelli S, Selli L, Fioretti A, Alexander DJ, Tollis M, Krauss S, Webster RG (2001) Characterization of H5N2 influenza viruses from Italian poultry. J Gen Virol 82:623–630PubMedGoogle Scholar
  6. 6.
    Guo YJ, Xu XY, Cox NJ (1992) Human influenza A (H1N2) viruses isolated from China. J Gen Virol 73(Pt 2):383–387PubMedCrossRefGoogle Scholar
  7. 7.
    Koopmans M, Wilbrink B, Conyn M, Natrop G, van der Nat H, Vennema H, Meijer A, van Steenbergen J, Fouchier R, Osterhaus A, Bosman A (2004) Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in The Netherlands. Lancet 363:587–593PubMedCrossRefGoogle Scholar
  8. 8.
    Lamb RA, Krug RM (2001) Orthomyxoviridae: the viruses and their replication. In: Howley DMKaPM (ed) Fields virology. Lippincott, Williams & Wilkins, Philadelphia, pp 1487–1531Google Scholar
  9. 9.
    Lee CW, Senne DA, Suarez DL (2004) Effect of vaccine use in the evolution of Mexican lineage H5N2 avian influenza virus. J Virol 78:8372–8381PubMedCrossRefGoogle Scholar
  10. 10.
    Meyer HM Jr, Hilleman MR, Miesse ML, Crawford IP, Bankhead AS (1957) New antigenic variant in far east influenza epidemic 1957. Proc Soc Exp Biol Med 95:609–616PubMedGoogle Scholar
  11. 11.
    Myers KP, Olsen CW, Setterquist SF, Capuano AW, Donham KJ, Thacker EL, Merchant JA, Gray GC (2006) Are swine workers in the United States at increased risk of infection with zoonotic influenza virus? Clin Infect Dis 42:14–20PubMedCrossRefGoogle Scholar
  12. 12.
    Myers KP, Setterquist SF, Capuano AW, Gray GC (2007) Infection due to 3 avian influenza subtypes in United States veterinarians. Clin Infect Dis 45:4–9PubMedCrossRefGoogle Scholar
  13. 13.
    Ogata T, Yamazaki Y, Okabe N, Nakamura Y, Tashiro M, Nagata N, Itamura S, Yasui Y, Nakashima K, Doi M, Izumi Y, Fujieda T, Yamato S, Kawada Y (2008) Human H5N2 avian influenza infection in japan and the factors associated with high H5N2-neutralizing antibody titer. J Epidemiol 18:160–166PubMedCrossRefGoogle Scholar
  14. 14.
    Okamatsu M, Saito T, Mase M, Tsukamoto K, Yamaguchi S (2007) Characterization of H5N2 influenza A viruses isolated from chickens in Japan. Avian Dis 51:474–475PubMedCrossRefGoogle Scholar
  15. 15.
    Okamatsu M, Saito T, Yamamoto Y, Mase M, Tsuduku S, Nakamura K, Tsukamoto K, Yamaguchi S (2007) Low pathogenicity H5N2 avian influenza outbreak in Japan during the 2005–2006. Vet Microbiol 124:35–46PubMedCrossRefGoogle Scholar
  16. 16.
    Olsen CW, Brammer L, Easterday BC, Arden N, Belay E, Baker I, Cox NJ (2002) Serologic evidence of H1 swine influenza virus infection in swine farm residents and employees. Emerg Infect Dis 8:814–819PubMedGoogle Scholar
  17. 17.
    ProMED-mail (2006) Avian influenza H5N2, human—Japan (Ibaraki) (02). ProMED-mail 2006: 2006 0110.0090Google Scholar
  18. 18.
    ProMED-mail (2006) Avian influenza H5N2, human—Japan (Ibaraki) (04). ProMED-mail: 2006,0112.0111Google Scholar
  19. 19.
    Rowe T, Abernathy RA, Hu-Primmer J, Thompson WW, Lu X, Lim W, Fukuda K, Cox NJ, Katz JM (1999) Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays. J Clin Microbiol 37:937–943PubMedGoogle Scholar
  20. 20.
    Saito T, Lim W, Suzuki T, Suzuki Y, Kida H, Nishimura SI, Tashiro M (2001) Characterization of a human H9N2 influenza virus isolated in Hong Kong. Vaccine 20:125–133PubMedCrossRefGoogle Scholar
  21. 21.
    Shope RE (1958) Influenza: history, epidemiology, and speculation. Public Health Rep 73:165–178PubMedGoogle Scholar
  22. 22.
    Shu LL, Zhou NN, Sharp GB, He SQ, Zhang TJ, Zou WW, Webster RG (1996) An epidemiological study of influenza viruses among Chinese farm families with household ducks and pigs. Epidemiol Infect 117:179–188PubMedCrossRefGoogle Scholar
  23. 23.
    Stephenson I, Wood JM, Nicholson KG, Zambon MC (2003) Sialic acid receptor specificity on erythrocytes affects detection of antibody to avian influenza haemagglutinin. J Med Virol 70:391–398PubMedCrossRefGoogle Scholar
  24. 24.
    Stephenson I, Wood JM, Nicholson KG, Charlett A, Zambon MC (2004) Detection of anti-H5 responses in human sera by HI using horse erythrocytes following MF59-adjuvanted influenza A/duck/Singapore/97 vaccine. Virus Res 103:91–95PubMedCrossRefGoogle Scholar
  25. 25.
    Subbarao K, Klimov A, Katz J, Regnery H, Lim W, Hall H, Perdue M, Swayne D, Bender C, Huang J, Hemphill M, Rowe T, Shaw M, Xu X, Fukuda K, Cox N (1998) Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279:393–396PubMedCrossRefGoogle Scholar
  26. 26.
    The Ministry of Agriculture, Forestry and Fisheries of Japan (2006) Statistical examination of stockbreeding, as of 1 February 2004; a tendency of domestication for pigs and hens in Japan. In: Statistics of agriculture, forestry and fisheries. Available from: http://www.maff.go.jp/toukei/sokuhou/data/tikusan2004-02/tikusan2004-02.pdf. Cited 30 April 2008
  27. 27.
    The Ministry of Health, Labor and Welfare of Japan (2006). The experimental results as of 10 January 2006; serological testing of anti-H5 influenza antibodies in human sera in Ibaraki and Saitama prefectures, Japan. Available from: http://www/mhlw.go.jp/houdou/2006/01/h0110-4.html. Cited 30 April 2008
  28. 28.
    Tweed SA, Skowronski DM, David ST, Larder A, Petric M, Lees W, Li Y, Katz J, Krajden M, Tellier R, Halpert C, Hirst M, Astell C, Lawrence D, Mak A (2004) Human illness from avian influenza H7N3, British Columbia. Emerg Infect Dis 10:2196–2199PubMedGoogle Scholar
  29. 29.
    Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y (1992) Evolution and ecology of influenza A viruses. Microbiol Rev 56:152–179PubMedGoogle Scholar
  30. 30.
    Webster RG, Govorkova EA (2006) H5N1 influenza—continuing evolution and spread. N Engl J Med 355:2174–2177PubMedCrossRefGoogle Scholar
  31. 31.
    World Health Organization (2002) WHO manual on animal influenza diagnosis and surveillance. Available from: http://whqlibdoc.who.int/hq/2002/WHO_CDS_CSR_NCS_2002.5.pdf. Cited 30 April 2008
  32. 32.
    World Health Organization (2008) Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to the WHO. Available from: http://www.who.int/csr/disease/avian_influenza/country/cases_table_2008_04_30/en/index.html. Cited 30 April 2008

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Yoshinao Yamazaki
    • 1
  • Mikio Doy
    • 3
    • 8
  • Nobuhiko Okabe
    • 2
  • Yoshinori Yasui
    • 2
  • Kazutoshi Nakashima
    • 2
  • Takashi Fujieda
    • 4
  • Shin-ichi Yamato
    • 5
  • Yuichi Kawata
    • 6
  • Tsuyoshi Ogata
    • 7
  1. 1.Department of Genetic ScienceIbaraki Prefectural Institute for Public HealthMitoJapan
  2. 2.Infectious Disease Surveillance Center, National Institute of Infectious DiseasesShinjukuJapan
  3. 3.Department of Health and WelfareIbaraki Prefectural GovernmentMitoJapan
  4. 4.Mito Public Health CenterMitoJapan
  5. 5.Tsuchiura Public Health CenterTsuchiuraJapan
  6. 6.Koga Public Health CenterKogaJapan
  7. 7.Chikusei Public Health CenterChikuseiJapan
  8. 8.Ibaraki Prefectural Central HospitalKasamaJapan

Personalised recommendations