Archives of Virology

, Volume 153, Issue 5, pp 979–982 | Cite as

Polymorphism of the PRNP gene in the main breeds of indigenous Chinese goats

  • R. Y. Zhou
  • X. L. LiEmail author
  • L. H. Li
  • H. Y. Wang
  • J. G. Lü
Brief Report


The polymorphism of the PRNP gene plays a key role in susceptibility to prion disease. Scrapie is a neurodegenerative disease affecting sheep and goats and belongs to the group of prion diseases. We isolated DNA from 333 goat samples representing the main local goat breeds in six provinces in China to identify PRNP polymorphisms and to determine whether these breeds were at risk for developing scrapie. Two novel amino acid polymorphisms (R211G and T219I) and a novel silent mutation at codon 125 as well as nine previously reported polymorphisms were observed. Twenty-eight alleles and forty-nine different genotypes were obtained. The codon 142M associated with resistance of goat scrapie was not found in this study. The codon 143R was relatively rare. The codon 222K, a potentially useful candidate site for selecting for scrapie resistance, was also rare in indigenous Chinese goats. These results could provide some useful data for assessing the risk of scrapie in Chinese indigenous goats.


Amino Acid Change Sichuan Province Prion Disease Bovine Spongiform Encephalopathy Hebei Province 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by national key scientific and technological project (2006BAD0410-06).


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • R. Y. Zhou
    • 1
  • X. L. Li
    • 1
    Email author
  • L. H. Li
    • 1
  • H. Y. Wang
    • 2
  • J. G. Lü
    • 3
  1. 1.College of Animal Science and TechnologyAgricultural University of HebeiBaodingPeople’s Republic of China
  2. 2.Animal Nutrition Center of Institute of Genetics and PhysiologyHebei Academy of Agriculture and Forestry SciencesShijiazhuangChina
  3. 3.Tangshan Animal Husbandry Workstation in Hebei provinceTangshanChina

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