Genetic analysis of four porcine avian influenza viruses isolated from Shandong, China
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A Bayesian phylogenetic analysis of eight separate gene segments indicated A/Swine/Shandong/2/2003 (H5N1), A/Swine/Shandong/na/2003 (H9N2), A/Swine/Shandong/nb/2003 (H9N2) and A/Swine/Shandong/nc/2005 (H9N2) probably represent two multiple reassortant lineages, that had not been described before, with genes coming from H5N1, H9N2 and other lineages from poultry in Asia. Amino acid motifs within the haemagglutinin sequence of A/Swine/Shandong/nb/2003 suggested it may be able to infect people, whereas the sequences of the other three isolates suggested they would not have had that capability. Our analysis emphasizes the need for a comprehensive study of the interactions between H5N1 and H9N2 viruses in Asia that includes sequencing and phylogenetic investigation.
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- Chen, H, Smith, GJD, Li, KS, Wang, J, Fan, XH, Rayner, JM, Vijaykrishna, D, Zhang, JX, Zhang, LJ, Guo, CT, Cheung, CL, Xu, KM, Duan, L, Huang, K, Qin, K, Leung, YHC, Wu, WL, Lu, HR, Chen, Y, Xia, NS, Naipospos, TSP, Yuen, KY, Hassan, SS, Bahri, S, Nguyen, TD, Webster, RG, Peiris, JSM, Guan, Y 2006Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic controlProc Natl Acad Sci USA10328452850PubMedCrossRefGoogle Scholar
- Guo, YJ, Li, JG, Cheng, XW, Wang, M, Zhou, Y, Li, XH, Cai, FC, Liao, HL, Zhang, H, Guo, JF, Huang, RM, Bei, D 1999Discovery of men infected by avian influenza A (H9N2) virusChin J Exp Clin Virol13105108Google Scholar
- Guo, YJ, Xie, JP, Wu, KY, Dong, J, Wang, M, Zhang, Y, Guo, JF, Chen, JM, Chen, ZF, Li, Z 2002Characterization of genome of A/Guangzhou/333/99 (H9N2) virusChin J Exp Clin Virol16142145Google Scholar
- Ha, Y, Stevens, D, Skehel, J, Wiley, D 2001X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogsProc Natl Acad Sci USA9989508955Google Scholar
- Li, KS, Guan, Y, Wang, J, Smith, GJD, Xu, KM, Duan, L, Rahardjo, AP, Puthavathana, P, Buranathai, C, Nguyen, TD, Estoepangestie, ATS, Chaisingh, A, Auewarakul, P, Long, HT, Hanh, NTH, Webby, RJ, Poon, LLM, Chen, H, Shortridge, KF, Yuen, KY, Webster, RG, Peiris, JSM 2004Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern AsiaNature430209213PubMedCrossRefGoogle Scholar
- Shi, WF, Yang, NN, Chen, D, Jin, X, Zhang, YZ, Zhu, CD 2007An X Genotype H5N1 virus was identified in Shandong in 2004Life Sci Res11177182Google Scholar