Archives of Virology

, Volume 153, Issue 1, pp 211–217 | Cite as

Genetic analysis of four porcine avian influenza viruses isolated from Shandong, China

  • W. F. Shi
  • M. J. Gibbs
  • Y. Z. Zhang
  • Z. Zhang
  • X. M. Zhao
  • X. Jin
  • C. D. Zhu
  • M. F. Yang
  • N. N. Yang
  • Y. J. Cui
  • L. Ji
Brief Report

Summary

A Bayesian phylogenetic analysis of eight separate gene segments indicated A/Swine/Shandong/2/2003 (H5N1), A/Swine/Shandong/na/2003 (H9N2), A/Swine/Shandong/nb/2003 (H9N2) and A/Swine/Shandong/nc/2005 (H9N2) probably represent two multiple reassortant lineages, that had not been described before, with genes coming from H5N1, H9N2 and other lineages from poultry in Asia. Amino acid motifs within the haemagglutinin sequence of A/Swine/Shandong/nb/2003 suggested it may be able to infect people, whereas the sequences of the other three isolates suggested they would not have had that capability. Our analysis emphasizes the need for a comprehensive study of the interactions between H5N1 and H9N2 viruses in Asia that includes sequencing and phylogenetic investigation.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Altschul, SF, Gish, W, Miller, W, Myers, EW, Lipman, DJ 1990Basic local alignment search toolJ Mol Biol215403410PubMedGoogle Scholar
  2. Butt, KM, Smith, GJD, Chen, HL, Zhang, LJ, Leung, YHC, Xu, KM, Lim, W, Webster, RG, Yuen, KY, Peiris, JSM, Guan, Y 2005Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003J Clin Microbiol4357605767PubMedCrossRefGoogle Scholar
  3. Chen, H, Smith, GJD, Li, KS, Wang, J, Fan, XH, Rayner, JM, Vijaykrishna, D, Zhang, JX, Zhang, LJ, Guo, CT, Cheung, CL, Xu, KM, Duan, L, Huang, K, Qin, K, Leung, YHC, Wu, WL, Lu, HR, Chen, Y, Xia, NS, Naipospos, TSP, Yuen, KY, Hassan, SS, Bahri, S, Nguyen, TD, Webster, RG, Peiris, JSM, Guan, Y 2006Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic controlProc Natl Acad Sci USA10328452850PubMedCrossRefGoogle Scholar
  4. Choi, YK, Ozaki, H, Webby, RJ, Webster, RG, Peiris, JS, Poon, L, Butt, C, Leung, YHC, Guan, Y 2004Continuing evolution of H9N2 influenza viruses in southern ChinaJ Virol7886098614PubMedCrossRefGoogle Scholar
  5. Claas, ECJ, Osterhaus, ADME, Van Beek, R, De Jong, JC, Rimmelzwaan, GF, Senne, DA, Krauss, S, Shortridge, KF, Webster, RG 1998Human influenza A H5N1 virus related to a highly pathogenic avian influenza virusLancet351472477PubMedCrossRefGoogle Scholar
  6. Guan, Y, Shortridge, KF, Krauss, S, Webster, RG 2000Molecular characterization of H9N2 influenza viruses: Were they the donors of the “internal” genes of H5N1 viruses in Hong Kong?Proc Natl Acad Sci USA9693639367CrossRefGoogle Scholar
  7. Guo, YJ, Krauss, S, Senne, DA, Mo, IP, Lo, KS, Xiong, XP, Norwood, M, Shortridge, KF, Webster, RG, Guan, Y 2000Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in AsiaVirology267279288PubMedCrossRefGoogle Scholar
  8. Guo, YJ, Li, JG, Cheng, XW, Wang, M, Zhou, Y, Li, XH, Cai, FC, Liao, HL, Zhang, H, Guo, JF, Huang, RM, Bei, D 1999Discovery of men infected by avian influenza A (H9N2) virusChin J Exp Clin Virol13105108Google Scholar
  9. Guo, YJ, Xie, JP, Wu, KY, Dong, J, Wang, M, Zhang, Y, Guo, JF, Chen, JM, Chen, ZF, Li, Z 2002Characterization of genome of A/Guangzhou/333/99 (H9N2) virusChin J Exp Clin Virol16142145Google Scholar
  10. Ha, Y, Stevens, D, Skehel, J, Wiley, D 2001X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogsProc Natl Acad Sci USA9989508955Google Scholar
  11. Horimoto, T, Kawaoka, Y 1994Reverse genetics provides direct evidence for a correlation of hemaggultinin cleavability and virulence of an avian influenza A virusJ Virol6831203128PubMedGoogle Scholar
  12. Iwatsuki-Horimoto, K, Kanazawa, R, Sugii, S, Kawaoka, Y, Horimoto, T 2004The index influenza A virus subtype h5n1 isolated from a human in 1997 differs in its receptor-binding properties from a virulent avian influenza virusJ Gen Virol8510011005PubMedCrossRefGoogle Scholar
  13. Kumar, S, Tamura, K, Nei, M 2004MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignmentBrief Bioinform5150163PubMedCrossRefGoogle Scholar
  14. Li, KS, Guan, Y, Wang, J, Smith, GJD, Xu, KM, Duan, L, Rahardjo, AP, Puthavathana, P, Buranathai, C, Nguyen, TD, Estoepangestie, ATS, Chaisingh, A, Auewarakul, P, Long, HT, Hanh, NTH, Webby, RJ, Poon, LLM, Chen, H, Shortridge, KF, Yuen, KY, Webster, RG, Peiris, JSM 2004Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern AsiaNature430209213PubMedCrossRefGoogle Scholar
  15. Lu, JH, Liu, XF, Shao, WX, Liu, YL, Wei, DP, Liu, HQ 2005Phylogenetic analysis of eight genes of H9N2 subtype influenza virus: a mainland China strain possessing early isolates’ genes that have been circulatingVirus Genes31163169PubMedCrossRefGoogle Scholar
  16. Matrosovich, MN, Krauss, S, Webster, RG 2001H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificityVirology281156162PubMedCrossRefGoogle Scholar
  17. Matrosovich, M, Zhou, NN, Kawaoka, Y, Webster, RG 1999The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable propertiesJ Virol7311461155PubMedGoogle Scholar
  18. Peiris, M, Yuen, KY, Leung, CW, Chan, KH, Ip, PL, Lai, RW, Orr, WK, Shortridge, KF 1999Human infection with influenza H9N2Lancet354916917PubMedCrossRefGoogle Scholar
  19. Shi, WF, Yang, NN, Chen, D, Jin, X, Zhang, YZ, Zhu, CD 2007An X Genotype H5N1 virus was identified in Shandong in 2004Life Sci Res11177182Google Scholar
  20. Weis, W, Brown, JH, Cusack, S, Paulson, JC, Skehel, JJ, Wiley, DC 1988Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acidNature333426431PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • W. F. Shi
    • 1
  • M. J. Gibbs
    • 2
  • Y. Z. Zhang
    • 3
  • Z. Zhang
    • 4
  • X. M. Zhao
    • 1
  • X. Jin
    • 4
  • C. D. Zhu
    • 3
  • M. F. Yang
    • 1
  • N. N. Yang
    • 1
  • Y. J. Cui
    • 1
  • L. Ji
    • 5
  1. 1.Institute of Life SciencesTaishan Medical CollegeShandong Tai’anChina
  2. 2.Faculty of Science, School of Botany and ZoologyAustralian National UniversityCanberraAustralia
  3. 3.Chinese Academy of Sciences, Institute of ZoologyBeijingChina
  4. 4.Department of Basic MedicineTaishan Medical CollegeShandong Tai’anChina
  5. 5.School of Public HealthGuangxi Medical UniversityGuangxi NanningChina

Personalised recommendations