Archives of Virology

, Volume 152, Issue 11, pp 2059–2072 | Cite as

Recent Korean isolates of duck hepatitis virus reveal the presence of a new geno- and serotype when compared to duck hepatitis virus type 1 type strains

  • M.-C. Kim
  • Y.-K. Kwon
  • S.-J. Joh
  • S.-J. Kim
  • C. Tolf
  • J.-H. Kim
  • H.-W. Sung
  • A. M. Lindberg
  • J.-H. Kwon


Duck hepatitis was first reported in 1985 in Korea. The complete nucleotide sequence of two past Korean isolates, DHV-HS and DHV-HSS, isolated in 1994 and 1995, and four recent Korean isolates, AP-03337, AP-04009, AP-04114 and AP-04203 isolated in 2003 and 2004, were determined. Phylogenetic analysis using the 3D protein sequence confirmed that the previously characterized duck hepatitis virus type 1 strains and the six Korean isolates described here constitute a monophyletic group and form two clades/genotypes in which all except the four recent Korean isolates form one group (A) and the recent Korean isolates of 2003 and 2004 constitute a second group (B). Phylogenetic analysis of the VP1 protein supported the division into two different groups. Antisera raised against viruses of group A showed significant neutralizing cross-reaction against a member of the same genotype but not to a strain of group B and vice versa. These results demonstrated that the two genotypes also could be regarded as two different serotypes.


Human Enterovirus Korean Isolate Duck Hepatitis Ljungan Virus Duck Hepatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • M.-C. Kim
    • 1
  • Y.-K. Kwon
    • 1
  • S.-J. Joh
    • 1
  • S.-J. Kim
    • 2
  • C. Tolf
    • 3
  • J.-H. Kim
    • 4
  • H.-W. Sung
    • 5
  • A. M. Lindberg
    • 3
  • J.-H. Kwon
    • 1
  1. 1.National Veterinary Research and Quarantine ServiceAnyangRepublic of Korea
  2. 2.BioPoA, Ltd., Business Incubating CenterSuwonRepublic of Korea
  3. 3.Department of Chemistry and Biomedical SciencesUniversity of KalmarKalmarSweden
  4. 4.College of Veterinary MedicineSeoul National UniversitySeoulRepublic of Korea
  5. 5.College of Veterinary MedicineKangwon National UniversityChuncheonRepublic of Korea

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