Archives of Virology

, Volume 152, Issue 10, pp 1925–1933

Genetic analysis of influenza A virus (H5N1) derived from domestic cat and dog in Thailand

  • A. Amonsin
  • T. Songserm
  • S. Chutinimitkul
  • R. Jam-on
  • N. Sae-Heng
  • N. Pariyothorn
  • S. Payungporn
  • A. Theamboonlers
  • Y. Poovorawan
Brief Report

Summary

Complete genome sequences of H5N1 viruses derived from a domestic cat “A/Cat/Thailand/KU-02/04” and dog “A/Dog/Thailand/KU-08/04” were comprehensively analyzed and compared with H5N1 isolates obtained during the 2004 and 2005 outbreaks. Phylogenetic analysis of both cat and dog viruses revealed that they are closely related to the H5N1 viruses recovered from avian influenza outbreaks of the same period. Genetic analysis of 8 viral gene segments showed some evidence of virulence in mammalian species. In summary, the H5N1 viruses that infected a domestic cat and dog are highly pathogenic avian influenza viruses that are virulent in mammalian species, potentially indicating transmission of H5N1 viruses from domestic animals to humans.

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References

  1. Amonsin, A, Payungporn, S, Theamboonlers, A, Thanawongnuwech, R, Suradhat, S, Pariyothorn, N, Tantilertcharoen, R, Damrongwantanapokin, S, Buranathai, C, Chaisingh, A, Songserm, T, Poovorawan, Y 2006Genetic characterization of H5N1 influenza A viruses isolated from zoo tigers in ThailandVirology344480491PubMedCrossRefGoogle Scholar
  2. Chen, H, Smith, GJ, Li, KS, Wang, J, Fan, XH, Rayner, JM, Vijaykrishna, D, Zhang, JX, Zhang, LJ, Guo, CT, Cheung, CL, Xu, KM, Duan, L, Huang, K, Qin, K, Leung, YH, Wu, WL, Lu, HR, Chen, Y, Xia, NS, Naipospos, TS, Yuen, KY, Hassan, SS, Bahri, S, Nguyen, TD, Webster, RG, Peiris, JS, Guan, Y 2006Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic controlProc Natl Acad Sci USA10328452850PubMedCrossRefGoogle Scholar
  3. Cheung, CL, Rayner, JM, Smith, GJ, Wang, P, Naipospos, TS, Zhang, J, Yuen, KY, Webster, RG, Peiris, JS, Guan, Y, Chen, H 2006Distribution of amantadine-resistant H5N1 avian influenza variants in AsiaJ Infect Dis19316261629PubMedCrossRefGoogle Scholar
  4. Cleaveland, S, Meslin, FX, Breiman, R 2006Dogs can play useful role as sentinel hosts for diseaseNature440605PubMedCrossRefGoogle Scholar
  5. Hatta, M, Gao, P, Halfmann, P, Kawaoka, Y 2001Molecular basis for high virulence of Hong Kong H5N1 influenza A virusesScience29318401842PubMedCrossRefGoogle Scholar
  6. Keawcharoen, J, Oraveerakul, K, Kuiken, T, Fouchier, RA, Amonsin, A, Payungporn, S, Noppornpanth, S, Wattanodorn, S, Theambooniers, A, Tantilertcharoen, R, Pattanarangsan, R, Arya, N, Ratanakorn, P, Osterhaus, DM, Poovorawan, Y 2004Avian influenza H5N1 in tigers and leopardsEmerg Infect Dis1021892191PubMedGoogle Scholar
  7. Krug, RM 2006Virology. Clues to the virulence of H5N1 viruses in humansScience31115621563PubMedCrossRefGoogle Scholar
  8. Le, QM, Kiso, M, Someya, K, Sakai, YT, Nguyen, TH, Nguyen, KH, Pham, ND, Ngyen, HH, Yamada, S, Muramoto, Y, Horimoto, T, Takada, A, Goto, H, Suzuki, T, Suzuki, Y, Kawaoka, Y 2005Avian flu: isolation of drug-resistant H5N1 virusNature4371108PubMedCrossRefGoogle Scholar
  9. Matrosovich, M, Zhou, N, Kawaoka, Y, Webster, R 1999The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable propertiesJ Virol7311461155PubMedGoogle Scholar
  10. Obenauer, JC, Denson, J, Mehta, PK, Su, X, Mukatira, S, Finkelstein, DB, Xu, X, Wang, J, Ma, J, Fan, Y, Rakestraw, KM, Webster, RG, Hoffmann, E, Krauss, S, Zheng, J, Zhang, Z, Naeve, CW 2006Large-scale sequence analysis of avian influenza isolatesScience31115761580PubMedCrossRefGoogle Scholar
  11. Office International des Epizooties O (2005) Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, Chapter 2.7.12 Avian Influenza. [Updated May 2005]Google Scholar
  12. Payungporn, S, Phakdeewirot, P, Chutinimitkul, S, Theamboonlers, A, Keawcharoen, J, Oraveerakul, K, Amonsin, A, Poovorawan, Y 2004Single-step multiplex reverse transcription-polymerase chain reaction (RT-PCR) for influenza A virus subtype H5N1 detectionViral Immunol17588593PubMedCrossRefGoogle Scholar
  13. Seo, SH, Hoffmann, E, Webster, RG 2004The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responsesVirus Res103107113PubMedCrossRefGoogle Scholar
  14. Shinya, K, Hamm, S, Hatta, M, Ito, H, Ito, T, Kawaoka, Y 2004PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in miceVirology320258266PubMedCrossRefGoogle Scholar
  15. Smith, GJ, Naipospos, TS, Nguyen, TD, de Jong, MD, Vijaykrishna, D, Usman, TB, Hassan, SS, Nguyen, TV, Dao, TV, Bui, NA, Leung, YH, Cheung, CL, Rayner, JM, Zhang, JX, Zhang, LJ, Poon, LL, Li, KS, Nguyen, VC, Hien, TT, Farrar, J, Webster, RG, Chen, H, Peiris, JS, Guan, Y 2006Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and VietnamVirology350258268PubMedCrossRefGoogle Scholar
  16. Songserm, T, Amonsin, A, Jam-on, R, Sae-Heng, N, Meemak, N, Pariyothorn, N, Payungporn, S, Theamboonlers, A, Poovorawan, Y 2006Avian influenza H5N1 in naturally infected domestic catEmerg Infect Dis12681683Google Scholar
  17. Songserm, T, Amonsin, A, Jam-on, R, Sae-Heng, N, Pariyothorn, N, Payungporn, S, Theamboonlers, A, Chutinimitkul, S, Thanawongnuwech, R, Poovorawan, Y 2006Fatal avian influenza A H5N1 in a dogEmerg Infect Dis1217441747PubMedGoogle Scholar
  18. van Riel, D, Munster, VJ, de Wit, E, Rimmelzwaan, GF, Fouchier, RA, Osterhaus, AD, Kuiken, T 2006H5N1 virus attachment to lower respiratory tractScience312399PubMedCrossRefGoogle Scholar
  19. Viseshakul, N, Thanawongnuwech, R, Amonsin, A, Suradhat, S, Payungporn, S, Keawchareon, J, Oraveerakul, K, Wongyanin, P, Plitkul, S, Theamboonlers, A, Poovorawan, Y 2004The genome sequence analysis of H5N1 avian influenza A virus isolated from the outbreak among poultry populations in ThailandVirology328169176PubMedCrossRefGoogle Scholar
  20. Zhou, H, Jin, M, Chen, H, Huag, Q, Yu, Z 2006Genome-sequence analysis of the pathogenic H5N1 avian influenza A virus isolated in China in 2004Virus Genes328595PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • A. Amonsin
    • 1
  • T. Songserm
    • 2
  • S. Chutinimitkul
    • 3
  • R. Jam-on
    • 2
  • N. Sae-Heng
    • 2
  • N. Pariyothorn
    • 1
  • S. Payungporn
    • 3
  • A. Theamboonlers
    • 3
  • Y. Poovorawan
    • 3
  1. 1.Faculty of Veterinary ScienceChulalongkorn UniversityPathumwanThailand
  2. 2.Faculty of Veterinary ScienceKasetsart UniversityKumphaengsaen CampusThailand
  3. 3.Faculty of MedicineChulalongkorn UniversityPathumwanThailand

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